Document Detail


Solid intraperitoneal Landschütz tumour in mice: implications in cancer chemotherapy and immunology studies.
MedLine Citation:
PMID:  1207037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple intraperitoneal injections of various normal sera into BALB/c mice inoculated intraperitoneally with Landschütz ascites tumour cells abrogated the development of ascitic syndrome in almost all the animals. In a large proportion of the survivors solid intraperitoneal tumours developed, composed of characteristic ascites tumour cells engulfed and encapsulated in connective tissue. The effect of serum on the development of the solid tumour was diminished if the donor had been immunized against mouse IgG. Inoculated animals treated with serum hyperimmune against mouse IgG showed accelerated ascitic tumour growth. Cyclophosphamide or arabinosylcytosine strongly inhibited growth of solid tumours. Simultaneous administration of arabinosylcytosine and its antagonist cycloheximide did not interrupt tumour growth.
Authors:
I Hod; A Zimber; D Gidoni; S Schonfeld
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animals     Volume:  9     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-03-05     Completed Date:  1976-03-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-27     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cycloheximide / therapeutic use
Cyclophosphamide / therapeutic use
Cytarabine / therapeutic use
Immune Sera
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neoplasms, Experimental* / drug therapy,  immunology
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Immune Sera; 147-94-4/Cytarabine; 50-18-0/Cyclophosphamide; 66-81-9/Cycloheximide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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