Document Detail

Solid and cystic acinar cell tumour of the pancreas. A tumour in young women with favourable prognosis.
MedLine Citation:
PMID:  7281507     Owner:  NLM     Status:  MEDLINE    
The clinico-pathological features of five cases with a distinctive pancreatic tumour are presented. The tumours, which occurred only in young women and an adolescent girl, were of large size (2.5-10 cm), had an uncharacteristic symptomatology and showed fibrous encapsulation with no evidence of metastases. The histological features include (1) solid areas with a monomorphic cell pattern and intracellular PAS positive globules, and (2) large foci of degeneration with cystic necroses, haemorrhages and cholesterol granulomas. Some tumour cells were positive for alpha1-antitrypsin. The ultrastructural demonstration of zymogen-like granules suggests an acinar origin for the tumours. We therefore propose the term solid and cystic acinar cell tumour. This tumour resembles the so called pancreatoblastomas in small children in some respects. It must be clearly distinguished, on the other hand, from acinar cell carcinoma with its acinic structures and poor prognosis. This lesion is not included in the WHO classification of pancreatic neoplasms.
G Klöppel; T Morohoshi; H D John; W Oehmichen; K Opitz; A Angelkort; H Lietz; K Rückert
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histology     Volume:  392     ISSN:  0340-1227     ISO Abbreviation:  Virchows Arch A Pathol Anat Histol     Publication Date:  1981  
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  7505137     Medline TA:  Virchows Arch A Pathol Anat Histol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  171-83     Citation Subset:  IM    
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MeSH Terms
Carcinoma / complications,  diagnosis,  pathology*
Cholesterol / analysis
Granuloma / complications
Pancreatic Neoplasms / complications,  diagnosis,  pathology*
Sex Factors
Reg. No./Substance:

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