| Solid cancer, antiphospholipid antibodies, and venous thromboembolism. | |
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MedLine Citation:
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PMID: 20955822 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The pathogenic role of antiphospholipid antibodies (aPL) in the development of venous thromboembolism (VTE) in patients with malignancies has not been established. From May 2006 to April 2008, 258 consecutive patients with solid-organ malignancies who developed VTE (VTE+) were recruited. A group of 142 patients matched for age, sex and tumor type cancer patients without VTE (VTE-) and an age-and-sex matched group of 258 healthy subjects were also included. A second blood sample was taken in positive aPL patients at least 12weeks later. Twenty-one (8.1%) VTE+ patients, 2 (1.4%) VTE- patients (p=0.006) and 2 (0.8%) healthy subjects (p<0.001) were positive for aPL. Persistent aPL positivity was observed in only 4 out of 15 available VTE+ patients. No differences in demographic characteristics, clinical pattern and outcome were observed in VTE+ patients according to aPL status. The low prevalence and transience of aPL positivity in patients with solid-organ malignancies with VTE argues against a pathogenic role in the development of thrombosis in this setting. The published evidence of the relationship between cancer, aPL, and thrombosis is reviewed. |
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Authors:
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Carme Font; Laura Vidal; Gerard Espinosa; Dolors Tàssies; Joan Monteagudo; Blanca Farrús; Laura Visa; Ricard Cervera; Pere Gascon; Joan C Reverter |
Publication Detail:
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Type: Journal Article Date: 2010-10-16 |
Journal Detail:
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Title: Autoimmunity reviews Volume: 10 ISSN: 1873-0183 ISO Abbreviation: Autoimmun Rev Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128967 Medline TA: Autoimmun Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 222-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Medical Oncology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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