Document Detail

Solicited adverse events after influenza immunization among infants, toddlers, and their household contacts.
MedLine Citation:
PMID:  16740837     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We assessed adverse events, including oculorespiratory syndrome, following influenza immunization during the first year of a publicly-funded program for infants, toddlers and their household members in Canada. METHODS: Parents bringing infants and toddlers for influenza immunization to clinics in Quebec or British Columbia consented to structured telephone interview 5 to 10 days later. One adult provided information for all household members. Symptom experience commencing before and after immunization was assessed. Non-immunized persons also served as a comparison group for immunized household members. RESULTS: Sample included 690 immunized infants and toddlers and 1801 household members, 1374 immunized. Only fussiness, fever, decreased appetite, drowsiness, and nasal congestion/coryza were reported for >5% of infants/ toddlers within 72 hours of immunization, but only arm discomfort was reported among >5% of immunized household contacts. In multivariate analysis, muscle ache was the only systemic symptom reported more often by immunized household members compared to non-immunized persons. Oculorespiratory symptoms were infrequent and there was no difference between immunized and non-immunized household members in their report. Less than 1% of adults required time off work because of adverse events following influenza immunization in the household. Less than 2% of subjects experiencing an adverse event following influenza immunization were considered unlikely to be vaccinated again. CONCLUSION: Influenza vaccine is well-tolerated by infants, toddlers and their household members. Post-marketing observational designs are an expedient way to assess adverse events following influenza immunization. These methods should be established and rehearsed annually in preparation for a pandemic.
Danuta M Skowronski; Karen Jacobsen; Jocelyne Daigneault; Valencia P Remple; Linda Gagnon; Patricia Daly; Gillian Arsenault; Monique Landry; Karen Pielak; Bernard Duval; Theresa Tam; Gaston De Serres
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  117     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-02     Completed Date:  2006-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1963-71     Citation Subset:  AIM; IM    
British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
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MeSH Terms
Child, Preschool
Family Health*
Influenza Vaccines / adverse effects*
Multivariate Analysis
Vaccines, Inactivated / adverse effects*
Reg. No./Substance:
0/Influenza Vaccines; 0/Vaccines, Inactivated; 0/vaxigrip

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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