| Soleus muscle atrophy in rats induced by cast immobilization: lack of effect by anabolic steroids. | |
MedLine Citation:
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PMID: 3341898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that an anabolic steroid such as nandrolone decanoate (ND) will ameliorate or abolish disuse-mediated alterations resulting from five weeks of hindlimb immobilization, female Sprague-Dawley rats were divided into six groups: control, control + ND, shortened-immobilized, shortened-immobilized + ND, stretched-immobilized, and stretched-immobilized + ND. Immobilization was accomplished by wrapping hindlimbs with plaster of Paris. Nandrolone decanoate in sesame oil was administered via weekly intraperitoneal injection (7 mg/kg) while nontreated rats received equivalent volumes of the vehicle. After five weeks selected morphometric, biochemical, and mechanical parameters were examined in the slow-twitch soleus muscle (SOL). Muscle wet weight fell from a control value of 145 +/- 19 mg to 70 +/- 8 mg (p less than .05) in the immobilized-shortened group where ND had no effect (81 +/- 11 mg). Muscle stretch alone prevented weight loss (159 +/- 31 mg). The addition of ND resulted in significant SOL hypertrophy (200 +/- 42 mg), p less than .05. Immobilization resulted in a significant shift in muscle protein distribution toward sarcoplasmic protein, a change unaltered by ND but abolished by stretch. Muscle strength, as indicated by peak tetanic tension, fell 45% (p less than .05) as a result of shortened immobilization. Nandrolone decanoate had no effect on this condition, although the ameliorating effect of stretch was abolished when in combination with ND treatment. The elevation observed in maximal shortening velocity (shortened-immobilized) was unaffected by ND alone, but abolished by stretch with or without ND treatment.(ABSTRACT TRUNCATED AT 250 WORDS) |
Authors:
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F A Witzmann |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Archives of physical medicine and rehabilitation Volume: 69 ISSN: 0003-9993 ISO Abbreviation: Arch Phys Med Rehabil Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-03-15 Completed Date: 1988-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985158R Medline TA: Arch Phys Med Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 81-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Biology, Indiana University-Purdue University at Indianapolis, Columbus 47203. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Casts, Surgical / adverse effects* Drug Evaluation, Preclinical Electric Stimulation Female Muscle Contraction / drug effects Muscles / drug effects, pathology Muscular Atrophy / drug therapy, etiology*, pathology Nandrolone / analogs & derivatives*, therapeutic use Rats Rats, Inbred Strains Time Factors |
| Chemical | |
Reg. No./Substance:
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360-70-3/nandrolone decanoate; 434-22-0/Nandrolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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