Document Detail

Solar simulated ultraviolet radiation damages murine neonatal skin and alters Langerhans cell development, but does not induce inflammation.
MedLine Citation:
PMID:  19492117     Owner:  NLM     Status:  MEDLINE    
Development of melanoma has been linked to excessive childhood exposure to sunlight. As neonates have a relatively underdeveloped immune system, it is likely that the immune system reacts differently to the exposure, leading to alterations in this development. This study was designed to assess changes in development of the skin immune system following neonatal irradiation. Ultraviolet radiation exposure led to relative depletion of Langerhans cells, however this was not due to migration or cell death, but rather restriction of Langerhans cells populating the epidermis. During this time, there was evidence of cellular damage, however there was no induction of an inflammatory response. It therefore appears that neonatal exposure to ultraviolet radiation leads to a skew towards a tolerogenic immune response, which may lead to a reduced ability to respond to ultraviolet radiation-induced tumours.
Heather M McGee; Thanuja Dharmadasa; Gregory M Woods
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-11
Journal Detail:
Title:  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology     Volume:  8     ISSN:  1474-905X     ISO Abbreviation:  Photochem. Photobiol. Sci.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124451     Medline TA:  Photochem Photobiol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  881-6     Citation Subset:  IM    
Menzies Research Institute, University of Tasmania, Hobart, Australia.
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MeSH Terms
Animals, Newborn
Apoptosis / radiation effects
Cell Movement / radiation effects
DNA Damage
Langerhans Cells / immunology,  pathology*,  radiation effects*
Lymph Nodes / immunology,  radiation effects
Radiation Injuries, Experimental / immunology*,  pathology*
Skin / immunology*,  pathology,  radiation effects*
Sunburn / pathology
Ultraviolet Rays / adverse effects*

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