Document Detail


Solar-simulated radiation induces secretion of IL-6 and production of isoprostanes in human skin in vivo.
MedLine Citation:
PMID:  16491351     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines represent an integral part of the large group of mediators involved in dermal inflammation. In this in vivo study, ultraviolet light which is one of the major environmental factors affecting cytokine release patterns in the skin was employed. The effects of repeated versus one-time irradiation with solar-simulated ultraviolet light was studied regarding the secretion of proinflammatory cytokines with a Bio-Plex cytokine assay using suction blisters as a model for localized inflammatory processes. The IL-6 concentration increased markedly after 24 h in skin areas irradiated with a twofold minimal erythemal dose (MED) compared to areas challenged repeatedly with 0.3 MED. In addition, we investigated the concentration of 8-isoprostane in the suction blister fluid as a marker of lipid peroxidation due to a UV-induced increase in free radical production. 8-Isoprostane was increased immediately after treatment but declined after 24 h with the exception of the skin area exposed to 2 MED. The differential expression and release of cytokines, and the extent of oxidative damage might therefore depend on the dose and regimen of exposure to solar-simulated radiation.
Authors:
Michaela Kuhn; Rainer Wolber; Ludger Kolbe; Oliver Schnorr; Helmut Sies
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-02-21
Journal Detail:
Title:  Archives of dermatological research     Volume:  297     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-09-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  477-9     Citation Subset:  IM    
Affiliation:
Institute for Biochemistry and Molecular Biology I, Heinrich-Heine University Duesseldorf, Building 22.03, Universitaetsstr.1, 40225, Duesseldorf, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blister / metabolism,  pathology
Cytokines / genetics,  metabolism
Dinoprost / analogs & derivatives*,  genetics,  metabolism
Dose-Response Relationship, Radiation
Free Radicals
Gene Expression Regulation / radiation effects
Humans
Inflammation / metabolism,  pathology
Interleukin-6 / genetics,  metabolism*
Lipid Peroxidation
Oxidative Stress
Skin / metabolism*,  radiation effects*
Time Factors
Ultraviolet Rays / adverse effects*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Free Radicals; 0/Interleukin-6; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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