| Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells. | |
| | |
MedLine Citation:
|
PMID: 20530426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains. |
| | |
Authors:
|
Yuan-Man Hsu; Chih-Ho Lai; Chiu-Hsiang Su; Wei-Wen Kuo; Chao-Lin Kuo; Cheng-Kuang Hsu; Chien-Kuo Wang; Ching-Yao Chang; Jing-Gung Chung |
Related Documents
:
|
8722376 - Immune and inflammatory responses to helicobacter pylori infection. 10807406 - Gastric epithelial cell proliferation and apoptosis in helicobacter pylori-infected mice. 21991336 - Macropinocytosis of extracellular glutathione ameliorates tumor necrosis factor α rele... 16835926 - Human ceruminous gland: ultrastructure and histochemical analysis of antimicrobial and ... 7041546 - C-reactive protein and the acute phase response. 2439536 - Systemic and intestinal immunities after natural typhoid infection. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-06-09 Completed Date: 2010-06-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
|
Languages: eng Pagination: 1189-93 Citation Subset: IM |
Affiliation:
|
Department of Biological Science, China Medical University, Taichung, Taiwan, ROC. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
drug therapy,
microbiology,
pathology Apoptosis / drug effects* Cell Line, Tumor Epithelial Cells / drug effects, microbiology, pathology Helicobacter Infections / drug therapy*, pathology* Helicobacter pylori / drug effects*, growth & development Humans Microbial Sensitivity Tests Plant Extracts / pharmacology* Solanum / chemistry* Stomach Neoplasms / drug therapy, microbiology*, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: LA-12 Overcomes Confluence-dependent Resistance of HT-29 Colon Cancer Cells to Pt (II) Compounds.
Next Document: Interaction of cyclooxygenase 2 genotype and smoking habit in Taiwanese lung cancer patients.