Document Detail

Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells.
MedLine Citation:
PMID:  20530426     Owner:  NLM     Status:  MEDLINE    
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains.
Yuan-Man Hsu; Chih-Ho Lai; Chiu-Hsiang Su; Wei-Wen Kuo; Chao-Lin Kuo; Cheng-Kuang Hsu; Chien-Kuo Wang; Ching-Yao Chang; Jing-Gung Chung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-06-09     Completed Date:  2010-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1189-93     Citation Subset:  IM    
Department of Biological Science, China Medical University, Taichung, Taiwan, ROC.
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MeSH Terms
Adenocarcinoma / drug therapy,  microbiology,  pathology
Apoptosis / drug effects*
Cell Line, Tumor
Epithelial Cells / drug effects,  microbiology,  pathology
Helicobacter Infections / drug therapy*,  pathology*
Helicobacter pylori / drug effects*,  growth & development
Microbial Sensitivity Tests
Plant Extracts / pharmacology*
Solanum / chemistry*
Stomach Neoplasms / drug therapy,  microbiology*,  pathology
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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