Document Detail


Solanaceous steroidal glycoalkaloids and poisoning by Solanum torvum, the normally edible susumber berry.
MedLine Citation:
PMID:  18725244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ingestion of immature, environmentally stressed, or cultivar-specific Solanum species (particularly the potato) has been previously associated with gastrointestinal and neurological symptoms caused by solanaceous steroidal glycoalkaloids (SGAs). We report on two geographically, temporally disparate outbreaks of poisoning by susumber berries (Solanum torvum- Solanaceae) and on detection of alkaloids not present in non-toxic berries. Five family members in New York City participated in a traditional evening meal containing Jamaican susumber berries. All those consuming berries were symptomatic the following morning with varying degrees of gastrointestinal distress, dizziness, slurred speech, cranial nerve deficits, and ataxia. The most seriously afflicted patient developed hypertension, confusion, proximal upper extremity weakness, and hypercapnic respiratory failure requiring prolonged mechanical ventilation. A separate cohort of six patients in Toronto ate unripe Jamaican susumber berries. They presented 14h post-ingestion with varying degrees of diarrhea, weakness, facial paralysis, slurred speech, ataxia, early hypertension, and proximal weakness. Two patients had ventilatory decompensation; one required intubation. Poisonous berries appeared indistinguishable from non-toxic varieties. We isolated solasonine, larger amounts of solamargine, and other steroidal glycoalkaloids in the toxic berry strains. S. torvum poisoning can produce significant neurological and gastrointestinal effects which appear to be mediated by SGAs present in the berries.
Authors:
Silas W Smith; Esther Giesbrecht; Margaret Thompson; Lewis S Nelson; Robert S Hoffman
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Publication Detail:
Type:  Journal Article     Date:  2008-08-07
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  52     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2009-01-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  667-76     Citation Subset:  IM    
Affiliation:
New York University School of Medicine, New York, USA. Silas.Smith@nyumc.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Foodborne Diseases / diagnosis,  epidemiology
Fruit / chemistry,  poisoning*
Humans
Middle Aged
Solanaceous Alkaloids / chemistry,  isolation & purification,  poisoning*
Solanum / chemistry,  poisoning*
Chemical
Reg. No./Substance:
0/Solanaceous Alkaloids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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