| Soft-tissue tumors: value of static and dynamic gadopentetate dimeglumine-enhanced MR imaging in prediction of malignancy. | |
| | |
MedLine Citation:
|
PMID: 15459325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To prospectively evaluate static and dynamic gadopentetate dimeglumine-enhanced magnetic resonance (MR) imaging relative to nonenhanced MR imaging in differentiation of benign from malignant soft-tissue lesions and to evaluate which MR imaging parameters are most predictive of malignancy, with associated interobserver variability. MATERIALS AND METHODS: One hundred forty consecutive patients (78 male patients [median age, 51 years], 62 female patients [median age, 53 years]) with a soft-tissue mass underwent nonenhanced static and dynamic contrast material-enhanced MR imaging. Diagnosis was based on histologic findings in surgical specimens (86 of 140), findings at core-needle biopsy (43 of 140), or results of all imaging procedures with clinical follow-up (11 of 140). Multivariate logistic regression analysis was used to identify the best combination of MR imaging parameters that might be predictive of malignancy. Subjective overall performance of two observers was evaluated with receiver operating characteristic analysis. RESULTS: For subjective overall diagnosis, area under the receiver operating characteristic curve, a measure for diagnostic accuracy, was significantly larger for combined nonenhanced and contrast-enhanced MR imaging than it was for nonenhanced MR imaging alone, with no significant difference between observers. Multivariate analysis of all lesions revealed that combined nonenhanced static and dynamic contrast-enhanced MR imaging parameters were significantly superior to nonenhanced MR imaging parameters alone and to nonenhanced MR imaging parameters combined with static contrast-enhanced MR imaging parameters in prediction of malignancy. The most discriminating parameters were presence of liquefaction, start of dynamic enhancement (time interval between start of arterial and tumor enhancement), and lesion size (diameter). Results for extremity lesions were the same, with one exception: With dynamic contrast-enhanced MR imaging parameters, diagnostic performance of one observer did not improve. CONCLUSION: Static and dynamic contrast-enhanced MR imaging, when added to nonenhanced MR imaging, improved differentiation between benign and malignant soft-tissue lesions. |
| | |
Authors:
|
Catharina S P van Rijswijk; Maarje J A Geirnaerdt; Pancras C W Hogendoorn; Antonie H M Taminiau; Frits van Coevorden; Aeilko H Zwinderman; Thomas L Pope; Johan L Bloem |
Related Documents
:
|
17882025 - Usefulness of fat-suppressed t1-weighted mri using orally administered superparamagneti... 7484575 - Mr diagnosis of hepatic metastases from neuroendocrine tumors versus hemangiomas: relat... 8739365 - Mri mapping of microvascular permeability and tissue blood volume. 16143105 - Rab conversion as a mechanism of progression from early to late endosomes. 22588265 - Differentiation of transverse sinus thrombosis from congenitally atretic cerebral trans... 7403545 - National cancer institute study: evaluation of computed tomography in the diagnosis of ... |
Publication Detail:
|
Type: Journal Article Date: 2004-09-30 |
Journal Detail:
|
Title: Radiology Volume: 233 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-11-01 Completed Date: 2004-11-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 493-502 Citation Subset: AIM; IM |
Affiliation:
|
Department of Radiology, Leiden University Medical Center, Bldg C3-Q, 2300 RC Leiden, the Netherlands. C.S.P.van_Rijswik@lumc.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Biopsy, Needle Child Child, Preschool Contrast Media* Female Gadolinium DTPA / diagnostic use* Humans Image Enhancement Infant Magnetic Resonance Imaging / methods* Male Middle Aged Observer Variation Prospective Studies ROC Curve Regression Analysis Soft Tissue Neoplasms / diagnosis*, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Autoimmune pancreatitis: imaging features.
Next Document: Multi-detector row CT: principles and practice for abdominal applications.