Document Detail


Soft tissue tumors in beagles injected with 241Am citrate.
MedLine Citation:
PMID:  7814256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The occurrence of soft tissue tumors has been studied in 117 beagles assigned to 8 dosage groups of between 2 and 26 animals each and injected with 0.07 to 104 kBq 241Am kg-1 as the citrate. In addition, 133 control beagles given no radioactivity were used as a comparison group. All 250 dogs were maintained under identical conditions and were observed for their entire lifespans. An important competing risk for the appearance of soft tissue tumors appeared to be the occurrence of skeletal malignancy, and at the highest injected activity (104 kBq kg-1), kidney and liver failure brought about the death of both of the two dogs in this group. Thyroid and liver were the only soft tissues that exhibited greater concentrations of 241Am than the skeleton. Liver tumors were associated with 241Am exposure (p < 0.001), but the thyroid tumor rate was not increased significantly in the irradiated animals (p > 0.10) as compared with the occurrence in controls. There was a greater relative occurrence of all vaginal tumors in control animals than in dogs given 241Am, a situation also found for all tumors of the pancreas, skin, testis, and mammary glands and for malignant ovarian tumors. All of these differences were statistically significant. The survival of animals given 0.07 to 0.59 kBq 241Am kg-1 could not be established (p > 0.10) as significantly different from controls, but the survival of all groups given 1.8 to 104 kBq kg-1 was decreased (p < 0.05). There was no indication in our studies of a positive association between relative exposure to 241Am and the occurrence of mammary tumors, mast cell sarcomas originating outside the liver, lymphosarcoma or tumors of marrow, including leukemia.
Authors:
R D Lloyd; G N Taylor; W Angus; S C Miller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Health physics     Volume:  68     ISSN:  0017-9078     ISO Abbreviation:  Health Phys     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-02-07     Completed Date:  1995-02-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985093R     Medline TA:  Health Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-33     Citation Subset:  IM    
Affiliation:
Radiobiology Laboratory, University of Utah, Salt Lake City 84112.
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MeSH Terms
Descriptor/Qualifier:
Americium / pharmacokinetics*
Animals
Citrates
Dogs
Dose-Response Relationship, Radiation
Metabolic Clearance Rate
Neoplasms, Experimental / etiology*
Neoplasms, Radiation-Induced*
Chemical
Reg. No./Substance:
0/Citrates; 7440-35-9/Americium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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