| Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome. | |
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MedLine Citation:
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PMID: 17122521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neoplasms that commonly affect patients with neurofibromatosis type 2 (NF2) include schwannomas, meningiomas, astrocytomas, ependymomas, and neurofibromas. Perineuriomas are rare tumors of the peripheral nerve sheath that share some characteristics with meningioma. As in both NF2-associated and sporadic cases of schwannoma and meningioma, perineuriomas often harbor mutations or deletions of the NF2 gene. However, perineuriomas have not previously been reported in the clinical setting of NF2. A 30-year-old man with a history of bilateral vestibular schwannomas, a parasagittal meningioma, an intraspinal ependymoma, and multiple other neoplasms involving both cranial and peripheral nerves (thereby fulfilling the diagnostic criteria for NF2) presented with an enlarging thigh mass. The diagnosis of cellular soft tissue perineurioma was confirmed by both immunohistochemical and ultrastructural analysis. This case represents the first report of a soft tissue perineurioma arising in the setting of NF2. |
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Authors:
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Clovis W Pitchford; Herbert S Schwartz; James B Atkinson; Justin M M Cates |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of surgical pathology Volume: 30 ISSN: 0147-5185 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-23 Completed Date: 2007-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 1624-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, TN 37232, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cytoplasm / ultrastructure Diagnosis, Differential Humans Male Neoplasms, Multiple Primary Nerve Sheath Neoplasms / chemistry, complications*, diagnosis, pathology, surgery Neurofibromatosis 2 / complications*, pathology Peripheral Nervous System Neoplasms / diagnosis Soft Tissue Neoplasms / chemistry, complications*, pathology, surgery Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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