| Soft tissue morphometry of the malleus-incus complex from micro-CT imaging. | |
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MedLine Citation:
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PMID: 18311579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The malleus-incus complex (MIC) is unique to mammalian hearing. To develop a comprehensive biomechanical MIC model for the human middle ear, measurements regarding its anatomical features are a necessity. Micro-scale X-ray computed tomography (micro-CT) imaging, which is known to be a suitable method for imaging high-density tissue such as middle-ear ossicles and surrounding bones, is used in this study to determine the three-dimensional (3-D) morphometry of the soft tissue attachments of the MIC. The MIC morphometry is based on their 3-D reconstruction from micro-CT image slices with resolutions ranging from 10 to 20 mum. The suspensory ligament and tendon attachments of the malleus and the incus as well as the incudomalleal joint (IMJ), are quantified in terms of dimensions, positions, and orientations for four human cadaver temporal bones. The malleus principal frame, the incus principal frame, and the MIC principle frame are calculated and the morphometry is reported in relation to each of these frames for the first time. The resulting values show significant variation across ear samples, suggesting that models of the MIC should be based on individual anatomy. The IMJ morphometry dimensions appear to be proportional to the ossicular mass. The micro-CT imaging modality is a nondestructive and relatively fast method for obtaining soft tissue morphometry and provides accurate anatomical features in relation to the principal axes of bones. |
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Authors:
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Jae Hoon Sim; Sunil Puria |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-03-03 |
Journal Detail:
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Title: Journal of the Association for Research in Otolaryngology : JARO Volume: 9 ISSN: 1438-7573 ISO Abbreviation: J. Assoc. Res. Otolaryngol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2009-04-30 Revised Date: 2011-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100892857 Medline TA: J Assoc Res Otolaryngol Country: United States |
Other Details:
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Languages: eng Pagination: 5-21 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA. jhsim@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Cadaver Humans Incus / anatomy & histology, radiography*, ultrastructure Ligaments, Articular / anatomy & histology* Malleus / anatomy & histology, radiography*, ultrastructure Models, Anatomic* Tendons / anatomy & histology* X-Ray Microtomography |
| Grant Support | |
ID/Acronym/Agency:
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DC005960/DC/NIDCD NIH HHS; R01 DC005960-07/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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