Document Detail


Sodwanones G, H, and I, new cytotoxic triterpenes from a marine sponge.
MedLine Citation:
PMID:  8594147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three cytotoxic triterpenes, sodwanones G [5], H [6], and I [7], have been isolated from a marine sponge. The three structures were determined by interpretation of nmr spectra, and in the case of 5, also on the basis of the X-ray diffraction analysis. The X-ray diffraction analysis of two other earlier reported sodwanones, E [3] and F [4] is also discussed. The cytotoxic activity against several cancer cell lines, has been tested. IC50 values between 20 and 0.02 microM were obtained. Compounds 5 and 6 were 10- and 500-fold, respectively, more cytotoxic to A-549 cells than to any of the other cell lines tested (HT-29, MEL-28, P-388).
Authors:
A Rudi; I Goldberg; Z Stein; Y Kashman; Y Benayahu; M Schleyer; M D Garcia Gravalos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  58     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-04-10     Completed Date:  1996-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1702-12     Citation Subset:  IM    
Affiliation:
School of Chemistry, Tel-Aviv University, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemistry,  isolation & purification*,  pharmacology
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Mice
Molecular Conformation
Porifera / chemistry*
Triterpenes / chemistry,  isolation & purification*,  pharmacology
Tumor Cells, Cultured
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Triterpenes; 0/sodwanone G; 0/sodwanone H; 0/sodwanone I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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