Document Detail

Sodium and water profiling in chronic uraemia.
MedLine Citation:
PMID:  9044339     Owner:  NLM     Status:  MEDLINE    
Haemodialysis is frequently complicated by side-effects both during and after treatment. Hypotension and muscle cramps have been attributed to depletion of intravascular volume; headache and fatigue have been attributed to rapid changes in intracellular and extracellular osmolality. An evidence-based systematic review of the English language literature was used to evaluate these hypotheses. Four studies have addressed the morbidity associated with changes in intravascular volume. These data suggest that during haemodialysis the vascular space is refilled from the interstitial space. Overhydrated patients are less likely to experience hypotension than are dehydrated patients, perhaps at the risk of congestive heart failure and hypertension. Intradialytic changes in haematocrit reflect changes in vascular volume and may be used to predict intradialytic hypotension. Eight studies have addressed the morbidity associated with changes in osmolality. In two of these studies the investigators reported clinical benefit for patients with patient-specific sodium profiles during dialysis. Four studies lacked sufficient statistical power to detect an effect of sodium profiling on patient symptoms. Two studies suggest a clinically important decrease in intradialytic symptoms during treatment with sodium-profiled dialysate. A definitive test of these hypotheses will require a randomized, blinded study of the clinical impact of sodium/ultrafiltration modelling on patient symptoms.
D N Churchill
Related Documents :
8184149 - A study of 500 cases of acute renal failure (1978-1991).
3627319 - Erythrocyte sodium transport in normotensive and hypertensive patients on chronic hemod...
6885959 - Dialysis encephalopathy and aluminum exposure: an epidemiologic analysis.
11244309 - Haemodialysis and cerebral oedema.
18711879 - Risk factors affecting nutritional status of dialysis patients: a quality improvement p...
12425489 - Characterization of treatment dose delivered by albumin dialysis in the treatment of ac...
21422649 - Restless legs syndrome in patients on hemodialysis.
2621769 - Silent myocardial ischemia during holter monitoring in ischemic heart disease.
8214319 - Selected problems treated by vocal fold injection of collagen.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  11 Suppl 8     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1996  
Date Detail:
Created Date:  1997-05-13     Completed Date:  1997-05-13     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  38-41     Citation Subset:  IM    
Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Volume
Chronic Disease
Dialysis Solutions / therapeutic use
Osmolar Concentration
Renal Dialysis* / adverse effects
Sodium / administration & dosage,  metabolism*,  therapeutic use
Uremia / metabolism*,  physiopathology,  therapy*
Water / metabolism*
Reg. No./Substance:
0/Dialysis Solutions; 7440-23-5/Sodium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of sodium and ultrafiltration modelling on plasma volume changes and haemodynamic stabili...
Next Document:  Sodium profiling in elderly haemodialysis patients.