Document Detail

Sodium-wasting nephropathy caused by cisplatin in a patient with small-cell lung cancer.
MedLine Citation:
PMID:  14667276     Owner:  NLM     Status:  MEDLINE    
We describe a case of severe hyponatremia following chemotherapy administration in a patient with small-cell lung cancer. There was no evidence of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion. The clinical and laboratory findings were consistent with a sodium-wasting nephropathy complicating cisplatin administration. There are few well-documented reports of cisplatin-associated hyponatremia in the medical literature. We have summarized the relevant literature and attempted to define the differential diagnosis of hyponatremia in this setting. Most cases are accounted for by sodium-losing nephropathy of SIADH, but many reported cases contain insufficient data for classification. Appropriate attention to the evaluation of hyponatremia following platinum-based chemotherapy is needed to properly treat these conditions.
Akila V Iyer; Steven H Krasnow; D Robert Dufour; Anthony S Arcenas
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical lung cancer     Volume:  5     ISSN:  1525-7304     ISO Abbreviation:  Clin Lung Cancer     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-11     Completed Date:  2004-02-24     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  100893225     Medline TA:  Clin Lung Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-9     Citation Subset:  IM    
Veterans Affairs Medical Center, Washington, DC 20422, USA.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Biological Markers / blood
Blood Urea Nitrogen
Carcinoma, Small Cell / blood,  drug therapy*
Cisplatin / adverse effects*
Creatinine / blood
Diagnosis, Differential
Hyponatremia / blood,  chemically induced*,  diagnosis*
Inappropriate ADH Syndrome / blood,  chemically induced,  diagnosis
Kidney Diseases / blood,  chemically induced*,  diagnosis*
Lung Neoplasms / blood,  drug therapy*
Middle Aged
Sodium / blood
Tomography, X-Ray Computed
Reg. No./Substance:
0/Antineoplastic Agents; 0/Biological Markers; 15663-27-1/Cisplatin; 60-27-5/Creatinine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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