| Sodium valproate for prevention of early posttraumatic seizures. | |
| | |
MedLine Citation:
|
PMID: 20880456 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the preventive effect of sodium valproate on early posttraumatic seizures in traumatic brain injury (TBI) patients. METHODS: The retrospective study was based on 159 patients with TBI treated at Department of Neurosurgery, Nanjing General Hospital of Nanjing Command enrolled between January 1, 2008 and December 31, 2009. The in-hospital section of the retrospectively collected database includes information on age, sex, initial Glasgow Coma Score (GCS), results of CT scanning, operation, usage of sodium valproate, seizures in the first week after injury and outcome. RESULTS: Seven patients (4.4%) showed early posttraumatic seizures. Although the incidence was zero in patients who received sodium valproate treatment, the difference between the treatment and control groups was not statistically significant. Of the 87 severe TBI patients (GCS 3-8), 6 patients in the control group (6.9%) suffered from early seizures during the first week after TBI and no patient who received preventive therapy suffered from seizures. The difference between the treatment and the control groups was still not statistically significant. Of the 72 mild and moderate TBI patients (GCS 9-15), only 1 patient in the control group suffered from seizures and no patient in the treatment group suffered. CONCLUSIONS: Although the results suggest that the study is not sufficiently powerful to detect a clinically important difference in the seizure rates between the treatment and control groups, sodium valproate is effective in decreasing the risk of early posttraumatic seizures in severe TBI patients. Further prospective studies are recommended. |
| | |
Authors:
|
Chi-yuan Ma; Ya-jun Xue; Ming Li; Yang Zhang; Guang-zhao Li |
Related Documents
:
|
16049936 - Sickle cell disease: ischemia and seizures. 18705676 - Oxcarbazepine treatment in male epilepsy patients improves pre-existing sexual dysfunct... 15311346 - Non-epileptic seizures of the elderly. 7327466 - Investigations on epileptogenic lesions in relation between ages of the patients and se... 7094456 - The part-time milwaukee brace treatment of juvenile idiopathic scoliosis. long-term fol... 23481506 - Ratio of von willebrand factor propeptide to adamts13 is associated with severity of se... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association Volume: 13 ISSN: 1008-1275 ISO Abbreviation: Chin. J. Traumatol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100886162 Medline TA: Chin J Traumatol Country: China |
Other Details:
|
Languages: eng Pagination: 293-6 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China. machiyuan@msn.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical efficacy of artificial skin combined with vacuum sealing drainage in treating large-area sk...
Next Document: Analysis of injuries and treatment of 3,401 inpatients in 2008 Wenchuan earthquake--based on Chinese...