Document Detail

Sodium valproate: kinetic profile and effects on GABA levels in various brain areas of the rat.
MedLine Citation:
PMID:  6815713     Owner:  NLM     Status:  MEDLINE    
1. The kinetic profile of sodium valproate (VPA) and the GABA levels were studied in discrete brain areas of the rat after an i.p. injection of 200 mg/kg. The results were discussed comparatively with GABA-T and GAD activities reported in the literature. 2. VPA was rapidly distributed in brain areas; its concentrations, its kinetic parameters and the GABA levels after the drug administration were not uniform in the different brain areas studied. 3. The results showed a particular relation of the VPA to the olfactory bulbs; in this specific area the VPA effect on GABA level was stronger; the VPA apparent half life of elimination was longest; the VPA apparent disappearance rate constant was smallest; the initial GABA level was higher; the activities of GABA-T and GAD were higher than in other brain areas studied except the hypothalamus. 4. These data were correlated with the role of the olfactory bulbs in the behaviour of the rodents.
E Mesdjian; L Ciesielski; M Valli; B Bruguerolle; G Jadot; P Bouyard; P Mandel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  6     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1982  
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  223-33     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects,  metabolism*
Rats, Inbred Strains
Time Factors
Valproic Acid / blood,  metabolism*,  pharmacology
gamma-Aminobutyric Acid / metabolism*
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid; 99-66-1/Valproic Acid

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