Document Detail


Sodium transport in the rabbit connecting tubule.
MedLine Citation:
PMID:  7124947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Connecting tubules were dissected from rabbit kidneys and perfused in vitro with a solution identical to that in the bath. Transepithelial sodium fluxes were measured with 22Na. The mean lumen-to-bath flux was 33.7 +/- 3.4 peq . cm-1 . s-1 and the mean bath-to-lumen flux was 13.4 +/- 3.4 peq . cm-1 . s-1. Thus, the net sodium transport was 20.3 peq . cm-1 . s-1, which is approximately 3--4 times higher than the one previously measured in cortical collecting ducts under similar conditions. The sodium permeability calculated from the bath-to-lumen measurements corrected for mean voltage was 1.22 x 10(-5) cm .s-1. The mean transepithelial electrical resistance was 31 omega . cm2. This sodium permeability is much higher and the electrical resistance much lower than those in cortical collecting ducts. Spontaneous transepithelial voltage was oriented negative in the lumen and ranged up to -42 mV at low perfusion pressures. When the perfusion pressure was increased, the voltage decreased to approximately -5 mV without any measurable change in the electrical resistance or the lumen-to-bath sodium flux.
Authors:
A J Almeida; M B Burg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  243     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F330-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport, Active
Electric Conductivity
Epithelium / physiology
Kidney Tubules / physiology*
Kinetics
Perfusion
Rabbits
Sodium / metabolism*
Chemical
Reg. No./Substance:
7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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