Document Detail

Sodium sensitivity as a main determinant of blood pressure changes during early withdrawal in heavy alcoholics.
MedLine Citation:
PMID:  12500104     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Stimulated sympathetic nervous system, renin-angiotensin-aldosterone system, vasopressin, and cortisol are thought to affect blood pressure in early withdrawal of alcoholics. Hyperactivity of sodium-retaining systems with consequent volume expansion also could interact with sodium sensitivity as previously found in long-term withdrawing alcoholics. METHODS: To investigate this hypothesis, blood pressure and sodium balance were measured during the first 8 days of withdrawal in 18 chronic alcoholics on a 150 mM Na diet. Results were related to the Salt Sensitivity Index of blood pressure as measured in the same alcoholics after 1 year of abstinence. RESULTS: Early withdrawal study: there was a positive sodium balance (+288.6 +/- 45.6 mM; p < 0.0001) and rise in mean arterial pressure (+11.8 +/- 2.9 mm Hg; p = 0.001) during early withdrawal on 150 mM Na diet. Salt Sensitivity Study after long-term detoxification: the shift from low (55 mM) to high sodium (260 mM) intake produced a larger (p = 0.04) increase in mean arterial pressure in alcoholics (+9.3 +/- 2.0 mm Hg) than in 30 teetotal controls (+5.1 +/- 1.1) (Salt Sensitivity Index, 0.047 +/- 0.008 vs. 0.023 +/- 0.0053; p < 0.05). Changes in mean blood pressure during withdrawal were highly related to sodium sensitivity index (r = 0.8; p < 0.001). CONCLUSIONS: Early withdrawing alcoholics exposed to a normal sodium intake experience positive Na balance and increase in blood pressure that is related to sodium sensitivity measured after long-term detoxification. This suggests that salt sensitivity plays a key role in blood pressure regulation in early withdrawing alcoholics.
Cristiana Di Gennaro; Pier Paolo Vescovi; Angela Luciana Barilli; Cristina Giuffredi; Roberto Delsignore; Alberto Montanari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  26     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-24     Completed Date:  2003-06-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1810-5     Citation Subset:  IM    
Center for Study and Treatment of Alcoholism at the Dipartimento di Medicina Interna e Scienze Biomediche, University of Parma, Italy. panorama@ipruniv.cce.uni
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MeSH Terms
Alcoholism / metabolism*
Blood Pressure / physiology*
Hypertension / metabolism
Linear Models
Middle Aged
Sodium, Dietary / metabolism*
Substance Withdrawal Syndrome / metabolism*
Reg. No./Substance:
0/Sodium, Dietary

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