| Sodium sensitivity as a main determinant of blood pressure changes during early withdrawal in heavy alcoholics. | |
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MedLine Citation:
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PMID: 12500104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Stimulated sympathetic nervous system, renin-angiotensin-aldosterone system, vasopressin, and cortisol are thought to affect blood pressure in early withdrawal of alcoholics. Hyperactivity of sodium-retaining systems with consequent volume expansion also could interact with sodium sensitivity as previously found in long-term withdrawing alcoholics. METHODS: To investigate this hypothesis, blood pressure and sodium balance were measured during the first 8 days of withdrawal in 18 chronic alcoholics on a 150 mM Na diet. Results were related to the Salt Sensitivity Index of blood pressure as measured in the same alcoholics after 1 year of abstinence. RESULTS: Early withdrawal study: there was a positive sodium balance (+288.6 +/- 45.6 mM; p < 0.0001) and rise in mean arterial pressure (+11.8 +/- 2.9 mm Hg; p = 0.001) during early withdrawal on 150 mM Na diet. Salt Sensitivity Study after long-term detoxification: the shift from low (55 mM) to high sodium (260 mM) intake produced a larger (p = 0.04) increase in mean arterial pressure in alcoholics (+9.3 +/- 2.0 mm Hg) than in 30 teetotal controls (+5.1 +/- 1.1) (Salt Sensitivity Index, 0.047 +/- 0.008 vs. 0.023 +/- 0.0053; p < 0.05). Changes in mean blood pressure during withdrawal were highly related to sodium sensitivity index (r = 0.8; p < 0.001). CONCLUSIONS: Early withdrawing alcoholics exposed to a normal sodium intake experience positive Na balance and increase in blood pressure that is related to sodium sensitivity measured after long-term detoxification. This suggests that salt sensitivity plays a key role in blood pressure regulation in early withdrawing alcoholics. |
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Authors:
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Cristiana Di Gennaro; Pier Paolo Vescovi; Angela Luciana Barilli; Cristina Giuffredi; Roberto Delsignore; Alberto Montanari |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 26 ISSN: 0145-6008 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-24 Completed Date: 2003-06-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: United States |
Other Details:
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Languages: eng Pagination: 1810-5 Citation Subset: IM |
Affiliation:
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Center for Study and Treatment of Alcoholism at the Dipartimento di Medicina Interna e Scienze Biomediche, University of Parma, Italy. panorama@ipruniv.cce.uni |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcoholism / metabolism* Blood Pressure / physiology* Female Humans Hypertension / metabolism Linear Models Male Middle Aged Sodium, Dietary / metabolism* Substance Withdrawal Syndrome / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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