Document Detail

Sodium-renin-aldosterone relations in normal and hypertensive pregnancy.
MedLine Citation:
PMID:  3066399     Owner:  NLM     Status:  MEDLINE    
To examine the short-term regulation of sodium excretion, plasma volume, and the renin-aldosterone system in pregnancy, women in their first pregnancy received either a high-salt (HS) (250 mmol/day) or a low-salt (LS) (20 mmol/day) diet for 7 days during the second and third trimester and after delivery (total 213 studies). Twenty women, studied while normotensive during mid-pregnancy, developed pregnancy-induced hypertension (PIH) in the third trimester. There was slightly greater difficulty adapting to sodium depletion (LS diet) during normal pregnancy compared with postpartum. The final mean values for sodium excretion were 27 (SE 2), 28 (SE 3) and 14 (SE 4) mmol/day in the second and third trimester and postpartum respectively. Sodium excretion with the HS diet was similar at all stages and plasma volumes were maintained as effectively during pregnancy as after delivery following both diets. Plasma renin activity (PRA) and aldosterone concentration rose and fell significantly following the LS and HS diets but the sensitivity of renin response to changes in salt intake was blunted during normal pregnancy. Women who later developed PIH, when studied whilst normotensive, failed to stimulate plasma aldosterone after salt depletion in their second trimester and did not exhibit the 'sodium-independent' component of PRA seen in continuously normotensive subjects at this stage.
M A Brown; E Nicholson; E D Gallery
Related Documents :
3524919 - Effect of sodium intake and sodium delivery to the macula densa on renal renin content ...
22505509 - Assessment of long-axis ventricular function in the fetal heart with a tissue-tracking ...
3066399 - Sodium-renin-aldosterone relations in normal and hypertensive pregnancy.
11428579 - Effects of sodium lactate and other additives in a cooked ham product on sensory qualit...
3554999 - Pregnancy: an overfill or underfill state.
18255349 - Patient predictors of esophageal stricture development after photodynamic therapy.
20519249 - Transfer of a selected single blastocyst optimizes the chance of a healthy term baby: a...
15823619 - Fetal growth restriction is associated with increased apoptosis in the chorionic tropho...
67059 - The use of alpha fetoprotein in prenatal diagnosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  95     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-04-04     Completed Date:  1989-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1237-46     Citation Subset:  AIM; IM    
St George Hospital, Kogarah, NSW, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aldosterone / blood*
Blood Volume
Diet, Sodium-Restricted
Hypertension / blood*,  physiopathology
Pregnancy Complications, Cardiovascular / blood*,  physiopathology
Renin / blood*
Renin-Angiotensin System
Sodium / administration & dosage,  blood*
Time Factors
Reg. No./Substance:
52-39-1/Aldosterone; 7440-23-5/Sodium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Transvaginal pulsed Doppler ultrasound assessment of blood flow to the corpus luteum in IVF patients...
Next Document:  Can ultrasound reliably diagnose ectopic pregnancy?