Document Detail


Sodium-renin-aldosterone relations in normal and hypertensive pregnancy.
MedLine Citation:
PMID:  3066399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the short-term regulation of sodium excretion, plasma volume, and the renin-aldosterone system in pregnancy, women in their first pregnancy received either a high-salt (HS) (250 mmol/day) or a low-salt (LS) (20 mmol/day) diet for 7 days during the second and third trimester and after delivery (total 213 studies). Twenty women, studied while normotensive during mid-pregnancy, developed pregnancy-induced hypertension (PIH) in the third trimester. There was slightly greater difficulty adapting to sodium depletion (LS diet) during normal pregnancy compared with postpartum. The final mean values for sodium excretion were 27 (SE 2), 28 (SE 3) and 14 (SE 4) mmol/day in the second and third trimester and postpartum respectively. Sodium excretion with the HS diet was similar at all stages and plasma volumes were maintained as effectively during pregnancy as after delivery following both diets. Plasma renin activity (PRA) and aldosterone concentration rose and fell significantly following the LS and HS diets but the sensitivity of renin response to changes in salt intake was blunted during normal pregnancy. Women who later developed PIH, when studied whilst normotensive, failed to stimulate plasma aldosterone after salt depletion in their second trimester and did not exhibit the 'sodium-independent' component of PRA seen in continuously normotensive subjects at this stage.
Authors:
M A Brown; E Nicholson; E D Gallery
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  95     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-04-04     Completed Date:  1989-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1237-46     Citation Subset:  AIM; IM    
Affiliation:
St George Hospital, Kogarah, NSW, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldosterone / blood*
Blood Volume
Diet, Sodium-Restricted
Female
Humans
Hypertension / blood*,  physiopathology
Pregnancy
Pregnancy Complications, Cardiovascular / blood*,  physiopathology
Renin / blood*
Renin-Angiotensin System
Sodium / administration & dosage,  blood*
Time Factors
Chemical
Reg. No./Substance:
52-39-1/Aldosterone; 7440-23-5/Sodium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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