Document Detail

Sodium removal in peritoneal dialysis: the role of icodextrin and peritoneal dialysis modalities.
MedLine Citation:
PMID:  18985997     Owner:  NLM     Status:  MEDLINE    
One of the main goals of dialysis is the control of extracellular volume, because inadequate sodium and fluid removal result in fluid overload and increased mortality. In the present study, we evaluated the roles of continuous ambulatory peritoneal dialysis (CAPD), continuous cycling peritoneal dialysis (CCPD), and the use of icodextrin on sodium removal in 29 patients (n = 18 on CAPD, n = 11 on CCPD). Daily removal of sodium by each modality and dialysis adequacy by Kt/V and creatinine clearance were evaluated. A significantly higher amount of sodium was removed in CAPD patients than in CCPD patients, although peritoneal dialysis clearances were lower in CAPD, and no difference in daily ultrafiltration was observed between the modalities. In the CAPD group, patients using icodextrin for the long dwell showed significantly increased 24-hour sodium removal (218 +/- 65 mmol/L) as compared with patients not using icodextrin (96.3 +/- 58 mmol/L, p < 0.001); they also showed increased daily ultrafiltration (1685 +/- 302 mL vs. 717 +/- 440 mL, p < 0.001). In the CCPD group, 8 patients were using icodextrin for the long dwell, and they showed significantly increased sodium removal only for the day exchange (43 +/- 49 mmol/L) as compared with patients not using icodextrin (-60 +/- 6, p < 0.001). Hypertension was less common in the CAPD patients than in the CCPD patients. These results indicate that CAPD is a more efficient modality than CCPD for sodium removal. Icodextrin is an effective tool not only for increasing adequacy, but also for removing more sodium in both modalities.
Costas Fourtounas; Andreas Hardalias; Periklis Dousdampanis; Basil Papachristopoulos; Eirini Savidaki; Jannis G Vlachojannis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis     Volume:  24     ISSN:  1197-8554     ISO Abbreviation:  Adv Perit Dial     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-06     Completed Date:  2008-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104803     Medline TA:  Adv Perit Dial     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
Department of Internal Medicine-Nephrology, University of Patras, Patras, Greece.
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MeSH Terms
Glucans / pharmacology*
Glucose / pharmacology*
Hemodialysis Solutions / pharmacology*
Middle Aged
Peritoneal Dialysis*
Peritoneal Dialysis, Continuous Ambulatory
Peritoneum / metabolism*
Sodium / metabolism*
Reg. No./Substance:
0/Glucans; 0/Hemodialysis Solutions; 0/icodextrin; 50-99-7/Glucose; 7440-23-5/Sodium

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