| Sodium and potassium intake present a J-shaped relationship with arterial stiffness and carotid intima-media thickness. | |
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MedLine Citation:
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PMID: 23084712 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: The purpose of this study was to analyse the relationship between sodium and potassium intake and vascular structure and function and to ascertain whether said relationship follows the pattern of a J-shaped curve. METHODS: A cross-sectional study was carried out in a primary care setting. Three hundred fifty-one subjects from the Vasorisk study were included and ranged in age from 30 to 80 years (mean 54.8, SD 11.7); 219 (62.4%) were females. Sodium and potassium intake were evaluated by means of a food frequency questionnaire. Arterial stiffness was assessed according to pulse wave velocity (PWV), ambulatory arterial stiffness index (AASI, AASI_BPVR), and central and peripheral augmentation index (AIx). Carotid intima-media thickness (C-IMT) was evaluated by ultrasonography. RESULTS: Age was lower in the quartiles with the highest sodium intake (p < 0.05), and no difference was observed between the sexes. Mean C-IMT, CAIx, AASI and AASI_BPVR were higher in the quartiles with higher sodium intake (p < 0.05 for both AASI and AASI_BPVR). Sodium intake was negatively correlated with C-IMT (r = -0.121, p < 0.05), PWV (r = -0.114, p < 0.05), AASI and AASI_BPVR (r = -0.155, p < 0.01). Potassium intake was positively correlated with Cornell VDP (r = 0.119, p < 0.05), CAIx (r = 0.178, p < 0.01) and PAIx (r = 0.202, p < 0.01). After adjustment, the morphology of the relationship between arterial stiffness parameters and C-IMT with quartiles of sodium intake resembles a J-shaped curve. The relationship between central and peripheral AIx and C-IMT and potassium intake resembles a J-shaped curve. CONCLUSION: The relationship of sodium and potassium intake with vascular structure and function, as evaluated with C-IMT, PWV, AASI and peripheral and central AIx, resembles a J-shaped curve, which is similar to what has been proposed in the case of cardiovascular morbimortality. |
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Authors:
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Luis García-Ortiz; José I Recio-Rodríguez; Emiliano Rodríguez-Sánchez; María C Patino-Alonso; Cristina Agudo-Conde; Carmela Rodríguez-Martín; Carmen Castaño-Sánchez; Isabelle Runkle; Manuel A Gómez-Marcos |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-5 |
Journal Detail:
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Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Primary care Research unit, La Alamedilla, Sacyl. IBSAL, REDIAPP, Salamanca, Spain. Electronic address: Lgarciao@usal.es. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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