Document Detail

Sodium-potassium-ATPase activity is influenced by ethnic origin and not by obesity.
MedLine Citation:
PMID:  6310395     Owner:  NLM     Status:  MEDLINE    
Previous investigations have suggested that red-cell ouabain binding (an indirect measure of sodium-potassium-ATPase activity) is lower in severely obese patients than in normal controls. We now confirm that ouabain binding measures sodium-potassium-ATPase activity, and we demonstrate that the level of this activity is genetically determined. The activity of this enzyme differs in various ethnic and racial groups, relatively high levels being encountered in non-Jewish white subjects, particularly those with some Scandinavian ancestry. On the other hand, black, Asian, and Jewish white subjects have lower sodium-potassium-ATPase activity. In contrast, no difference was found in red-cell sodium-potassium-ATPase activity between severely obese and normal persons, nor could we confirm a putative effect of food intake on the level of the red-cell enzyme. We suggest that in most earlier studies in which differences were found between normal and severely obese persons, those differences could have been due to differences in the ethnic origins of the obese and control populations.
E Beutler; W Kuhl; P Sacks
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  309     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  756-60     Citation Subset:  AIM; IM    
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MeSH Terms
Erythrocytes / enzymology
Ethnic Groups*
Obesity / enzymology*
Ouabain / metabolism
Sodium-Potassium-Exchanging ATPase / blood*,  genetics
Grant Support
Reg. No./Substance:
630-60-4/Ouabain; EC ATPase

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