| Sodium polystyrene sulfonate used to reduce the potassium content of a high-protein enteral formula: a quantitative analysis. | |
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MedLine Citation:
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PMID: 15080600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sodium polystyrene sulfonate (Kayexalate) commonly is used in treating hyperkalemia. As a cation exchange resin, it also can be used to reduce the potassium content of enteral nutrition formulas. This study evaluates the use of Kayexalate to reduce potassium in one high-protein enteral formula and describes the quantitative analysis of the product. METHODS: Sodium polystyrene sulfonate and enteral formula were mixed into a slurry and allowed to settle, and then the supernatant was decanted off and tested as samples. Three sample concentrations were analyzed: a control not subjected to potassium reduction, 0.5 g of Kayexalate per mEq K+ sample, and a 1 g/mEq K+ sample. Of these samples, moisture, lipid, protein, carbohydrate, ash, and mineral content were obtained. RESULTS: Compared with the control, the percentage decrease of potassium ranged from 25% to 36%, depending on the concentration of Kayexalate. A significant increase of 324% in sodium concentration was found in the 1.0 g/mEq K+ sample. Although there was no change in magnesium content, a slight increase in phosphorus, iron, and zinc was evident. CONCLUSIONS: The treatment of an enteral formula with sodium polystyrene sulfonate significantly increases its sodium content, with a modest decrease in potassium content. Clinicians using this method in clinical practice should be aware of the increase in sodium content. |
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Authors:
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Andrew L Rivard; Sandra M Raup; Gregory J Beilman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 28 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 2004 Mar-Apr |
Date Detail:
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Created Date: 2004-04-14 Completed Date: 2005-04-08 Revised Date: 2007-02-21 |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 76-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cation Exchange Resins
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pharmacology Dose-Response Relationship, Drug Enteral Nutrition* Food, Formulated / analysis* Humans Polystyrenes / pharmacology* Potassium / analysis*, chemistry Sodium / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Cation Exchange Resins; 0/Polystyrenes; 28210-41-5/polystyrene sulfonic acid; 7440-09-7/Potassium; 7440-23-5/Sodium |
| Comments/Corrections | |
Comment In:
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JPEN J Parenter Enteral Nutr. 2004 Mar-Apr;28(2):124-7
[PMID:
15080609
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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