| Sodium oxybate for narcolepsy. | |
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MedLine Citation:
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PMID: 16893342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sodium oxybate (Xyrem), also known as gamma-hydroxybutyric acid, is the only therapeutic specifically approved in the USA for the treatment of cataplexy in narcolepsy. The US FDA has recently expanded its indication to include excessive daytime sleepiness associated with narcolepsy. In contrast to the antidepressants and stimulants commonly used to treat the disorder, sodium oxybate is the only compound that addresses both sets of symptoms and, when used properly, is less likely to lead to the development of tolerance and other undesirable side effects. In this review, the results of clinical trials and the place of sodium oxybate in narcolepsy treatment are discussed. |
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Authors:
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Martin B Scharf |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of neurotherapeutics Volume: 6 ISSN: 1744-8360 ISO Abbreviation: Expert Rev Neurother Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-08 Completed Date: 2006-09-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101129944 Medline TA: Expert Rev Neurother Country: England |
Other Details:
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Languages: eng Pagination: 1139-46 Citation Subset: IM |
Affiliation:
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The Center for Research in Sleep Disorders, 1275 Kemper Road Cincinnati, OH 45246-3901, USA. mscharf@tristatesleep.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Intravenous
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therapeutic use Cataplexy / drug therapy Europe / epidemiology Humans Incidence Narcolepsy / diagnosis, drug therapy*, epidemiology, physiopathology Sodium Oxybate / therapeutic use* United States / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 502-85-2/Sodium Oxybate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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