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Sodium oxybate increases prolactin secretion in narcolepsy patients and healthy controls.
MedLine Citation:
PMID:  21148631     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: Hypocretin deficiency causes narcolepsy and may affect neuroendocrine systems, including TSH, ACTH and LH secretion. Symptoms can be treated effectively with sodium oxybate (SXB) in many patients. This study was performed to compare prolactin secretion in patients and matched controls and establish the effect of SXB administration on prolactin and sleep in both groups. Design: Open label intervention. Blood was sampled before and after 5 days of SXB treatment. Methods: Subjects were admitted to the clinical research centre on both occasions. Patients or Participants: Eight male hypocretin deficient narcolepsy with cataplexy and eight controls matched for sex, age, BMI, waist-to-hip ratio,and fat percentage were enrolled. Interventions: SXB 2 times 3g per night for 5 consecutive nights. Results: Patients and controls underwent 24-h blood sampling at 10- min intervals for measurement of prolactinconcentrations. The prolactin concentration time series was analyzed with a new deconvolution program, approximate entropy (ApEn) and Cosinor analysis. Sleep was polygraphically recorded. Basal and pulsatile prolactin secretion, as well as pulse regularity and frequency, approximate entropy and diurnal parameters were similar in patients and controls. SXB treatment caused similar nocturnal increase of prolactin secretion, advance of the acrophase and decrease of ApEn in patients and controls. Slow wave sleep was increased to a similar extent in patients and controls. Conclusion: This detailed study did not demonstrate altered prolactin secretion in hypocretin-deficient narcolepsy patients during the basal state or during SXB administration. Therefore, hypocretin signalling is unlikely to be a regulator of the lactotropic system.
Authors:
Claire E H M Donjacour; N Ahmad Aziz; Marijke Frölich; Ferdinand Roelfsema; Sebastiaan Overeem; Gert Jan Lammers; Hanno Pijl
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-13
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
C Donjacour, Neurology, Leiden University Medical Centre, Leiden, Netherlands.
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