| Sodium nitroprusside-induced, but not desflurane-induced, hypotension decreases myocardial tissue oxygenation in dogs anesthetized with 8% desflurane. | |
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MedLine Citation:
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PMID: 12073197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare sodium nitroprusside (SNP)-induced hypotension with desflurane-induced hypotension for the effects on myocardial blood flow and tissue oxygenation in dogs. DESIGN: Prospective, randomized, crossover, nonblinded. SETTING: University teaching hospital. PARTICIPANTS: Male nonpurpose-bred hounds (n = 8). INTERVENTIONS: Dogs were anesthetized with 8% desflurane. Catheters were inserted into the femoral artery and coronary sinus. A flow probe was placed in the left anterior descending (LAD) branch of the coronary artery. A sensor that measured myocardial oxygen pressure (PmO(2)) was inserted into the myocardium of the left ventricle. Myocardial oxygen consumption (MVO(2)) was calculated as LAD flow x arterial - coronary sinus oxygen content. MEASUREMENTS AND MAIN RESULTS: Measurements were made at baseline blood pressure levels of 99 mmHg (measure 1), during hypotension to 62 to 66 mmHg using intravenous SNP or 14% desflurane (measure 2), and during SNP or 14% desflurane with blood pressure support using phenylephrine (measure 3). Each dog randomly received both hypotensive treatments, separated by 1 hour. Baseline measures were PmO(2) = 46 +/- 9 mmHg, LAD flow = 43 +/- 11 mL/min, and MVO(2) = 2.47 +/- 0.73 mL O(2)/min. During hypotension induced with SNP, PmO(2) decreased 30% (p < 0.05), LAD flow increased 40% (p < 0.05), and MVO(2) did not change. During hypotension induced with 14% desflurane, PmO(2) did not change, and LAD flow and MVO(2) decreased 25% and 40% (p < 0.05). Blood pressure support with phenylephrine increased LAD flow and MVO(2) but did not change PmO(2) during SNP or 14% desflurane treatment. CONCLUSION: SNP-induced hypotension produced myocardial vasodilation, but tissue oxygenation was impaired. PmO(2) was maintained during desflurane-induced hypotension. |
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Authors:
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William E Hoffman; Ronald F Albrecht; Zivojin S Jonjev |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 16 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-19 Completed Date: 2002-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 286-9 Citation Subset: IM |
Copyright Information:
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Copyright 2002, Elsevier Science (USA). All rights reserved. |
Affiliation:
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Departments of Anesthesiology and Physiology, University of Illinois at Chicago, Chicago, IL60612, USA. whoffman@uic.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia* Anesthetics, Inhalation / pharmacology* Animals Antihypertensive Agents / pharmacology* Blood Pressure / drug effects Carbon Dioxide / blood Coronary Circulation / drug effects Dogs Heart Rate / drug effects Hypotension / chemically induced, metabolism* Isoflurane / analogs & derivatives*, pharmacology* Male Myocardium / metabolism* Nitroprusside / pharmacology* Oxygen / blood, metabolism* Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Antihypertensive Agents; 124-38-9/Carbon Dioxide; 15078-28-1/Nitroprusside; 26675-46-7/Isoflurane; 57041-67-5/desflurane; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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