| Sodium nitroprusside enhanced cardiopulmonary resuscitation (SNPeCPR) improves vital organ perfusion pressures and carotid blood flow in a porcine model of cardiac arrest. | |
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MedLine Citation:
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PMID: 21864483 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purposeof the study: To describe a new method of CPR that optimizes vital organperfusionpressures and carotid blood flow.We tested the hypothesis that a combination of high dose sodium nitroprusside (SNP)as well asnon-invasive devices and techniques known independently to enhance circulation would significantly improve carotid blood flow (CBF) and return of spontaneous circulation (ROSC) rates in a porcine model of cardiac arrest. Methods:15 Isofluorane anesthetized pigs (30±1Kg), after 6minutes of untreated ventricular fibrillation, were subsequently randomized to receive either 15minutes of standard CPR (S-CPR) (8 animals) or 5minute epochs of S-CPR followed by active compression-decompression (ACD) +inspiratory impedance threshold device (ITD) CPR followed by ACD+ITD+abdominal binding (AB) with 1mg of SNP administered at minutes 2, 7, 12 of CPR (7 animals). Primary endpoints were CBF and ROSC rates. ANOVA and Fisher's exact test were used for comparisons. Results/Conclusion: There was significant improvement in the hemodynamic parameters in the SNP animals. ROSC was achieved in 7/7 animals that received SNP and in 2/8 in the S-CPR (p=0.007). CBF and end tidal CO(2)(ETCO(2)) were significantly higher in the ACD+ITD+AB+SNP (SNPeCPR) animals during CPR. Bolus doses of SNP, when used in conjunction with ACD+ITD+AB CPR, significantly improve CBF and ROSC rates compared to S-CPR. |
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Authors:
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Jason Schultz; Nicolas Segal; James Kolbeck; Scott McKnite; Emily Caldwell; Demetrisyannopoulos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
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Title: Resuscitation Volume: - ISSN: 1873-1570 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Medicine, University of Minnesota, Minneapolis, MN. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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