Document Detail

Sodium nitroprusside enhanced cardiopulmonary resuscitation (SNPeCPR) improves vital organ perfusion pressures and carotid blood flow in a porcine model of cardiac arrest.
MedLine Citation:
PMID:  21864483     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF THE STUDY: To describe a new method of CPR that optimizes vital organ perfusion pressures and carotid blood flow. We tested the hypothesis that a combination of high dose sodium nitroprusside (SNP) as well as non-invasive devices and techniques known independently to enhance circulation would significantly improve carotid blood flow (CBF) and return of spontaneous circulation (ROSC) rates in a porcine model of cardiac arrest.
METHODS: 15 isofluorane anesthetized pigs (30±1 kg), after 6 min of untreated ventricular fibrillation, were subsequently randomized to receive either 15 min of standard CPR (S-CPR) (8 animals) or 5 min epochs of S-CPR followed by active compression-decompression (ACD)+inspiratory impedance threshold device (ITD) CPR followed by ACD+ITD+abdominal binding (AB) with 1mg of SNP administered at minutes 2, 7, 12 of CPR (7 animals). Primary endpoints were CBF and ROSC rates. ANOVA and Fisher's exact test were used for comparisons.
RESULTS/CONCLUSION: There was significant improvement in the hemodynamic parameters in the SNP animals. ROSC was achieved in 7/7 animals that received SNP and in 2/8 in the S-CPR (p=0.007). CBF and end tidal CO(2) (ETCO(2)) were significantly higher in the ACD+ITD+AB+SNP (SNPeCPR) animals during CPR. Bolus doses of SNP, when used in conjunction with ACD+ITD+AB CPR, significantly improve CBF and ROSC rates compared to S-CPR.
Jason Schultz; Nicolas Segal; James Kolbeck; Scott McKnite; Emily Caldwell; Demetris Yannopoulos
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Publication Detail:
Type:  Journal Article     Date:  2011-08-22
Journal Detail:
Title:  Resuscitation     Volume:  83     ISSN:  1873-1570     ISO Abbreviation:  Resuscitation     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-06-19     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  374-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Analysis of Variance
Blood Flow Velocity
Cardiopulmonary Resuscitation / methods*
Carotid Arteries / physiology
Disease Models, Animal
Heart Arrest / therapy*
Nitroprusside / pharmacology*
Random Allocation
Regional Blood Flow
Vasodilator Agents / pharmacology*
Grant Support
Reg. No./Substance:
0/Vasodilator Agents; 169D1260KM/Nitroprusside

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