| Sodium-lithium countertransport in children with nephrotic syndrome. | |
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MedLine Citation:
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PMID: 10452280 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms of sodium retention in edema-forming minimal change nephrotic syndrome (MCNS) have not been completely evaluated. The aim of this study was to characterize the transmembrane sodium transport in nephrotic syndrome by measuring the erythrocyte sodium-lithium countertransport (SLC) in vitro. Eighteen children with MCNS were studied in the edema-forming state, and subsequently at the beginning of remission. Nephrotic children with edema retained sodium (10+/-12 micromol/day) and had a higher SLC [426+/-118 vs. 281+/-60 micromol/l red blood cells (RBC) per hour, P=0.003). The intracellular sodium concentration of nephrotics was 6.1+/-2.1 mmol/l RBC, which did not differ from that of controls (6.42+/-2.24, n=13). In remission sodium balance became negative (-30+/-21 mmol/day), and the SLC decreased but still differed significantly from control values (P=0.009). The intracellular sodium content decreased to 4.4+/-0.9 mmol/l RBC (P=0.002). There was a negative correlation between erythrocyte SLC and plasma albumin concentration (r=0.48, P=0.003), and urinary sodium excretion rate (r=0.66, P=0.001). In conclusion, erythrocyte SLC is high in the edema-forming state of childhood nephrotic syndrome and decreases with the onset of remission. A role for the SLC in the altered sodium homeostasis of nephrotic syndrome is suggested. |
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Authors:
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T Tulassay; M Dobos; A Luczay; G Stubnya; G S Reusz; B Vásárhelyi; P Sallay; A Szabó |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 13 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-09-16 Completed Date: 1999-09-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 510-3 Citation Subset: IM |
Affiliation:
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1st Department of Paediatrics, Semmelweis Medical University, Budapest, Hungary. tulas@gyer1.sote.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antiporters
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blood* Child Child, Preschool Edema / etiology Erythrocytes / metabolism Female Humans Male Natriuresis / physiology Nephrotic Syndrome / blood*, complications, physiopathology Reference Values Sodium / blood |
| Chemical | |
Reg. No./Substance:
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0/Antiporters; 0/sodium-lithium countertransporter; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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