Document Detail


Sodium-lithium countertransport and hypertension in Rochester, Minnesota.
MedLine Citation:
PMID:  1885226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objectives of the present study were to determine whether increased sodium-lithium countertransport is associated with essential hypertension in the general Caucasian population and to determine whether this association is independent of the effects of gender, age, body size, and plasma lipids. We studied 543 men and 589 women from the population of Rochester, Minnesota. Mean sodium-lithium countertransport was higher in hypertensive than in normotensive subjects in men (370 +/- 147 [mean +/- SD] versus 315 +/- 110 mumol/l red blood cells [RBC]/hr, p less than 0.001) and in women (339 +/- 114 versus 269 +/- 92 mumol/l RBC/hr, p less than 0.001). Interindividual differences in plasma triglycerides, body mass index (wt/[ht]2), and plasma total cholesterol explained 13.0% of sodium-lithium countertransport variation in men (p less than 0.001) and 20.2% in women (p less than 0.001). Age did not predict additional sodium-lithium countertransport variation in either gender. Slopes of the regressions of sodium-lithium countertransport on plasma triglycerides, body mass index, and plasma total cholesterol did not differ between diagnostic groups in men (p = 0.31) or in women (p = 0.29). After adjustment to remove sodium-lithium countertransport variation attributable to these covariates, mean sodium-lithium countertransport remained significantly higher in hypertensive than in normotensive subjects in men (354 +/- 139 versus 319 +/- 104 mumol/l RBC/hr, p less than 0.01) and in women (311 +/- 103 versus 278 +/- 83 mumol/l RBC/hr, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S T Turner; V V Michels
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  18     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-08     Completed Date:  1991-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-90     Citation Subset:  IM    
Affiliation:
Division of Hypertension and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Apolipoproteins A / blood
Apolipoproteins E / blood
Biological Transport, Active
Blood Pressure
Body Mass Index
Cholesterol / blood
European Continental Ancestry Group
Female
Humans
Hypertension / metabolism*
Lithium / metabolism*
Male
Middle Aged
Minnesota
Regression Analysis
Sex Factors
Sodium / metabolism*
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
HL-24489/HL/NHLBI NIH HHS; HL-30428/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins A; 0/Apolipoproteins E; 0/Triglycerides; 57-88-5/Cholesterol; 7439-93-2/Lithium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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