Document Detail

Sodium-lithium countertransport and family history of hypertension in childhood.
MedLine Citation:
PMID:  8155926     Owner:  NLM     Status:  MEDLINE    
We have studied the relationship between sodium-lithium countertransport, determined in childhood, and family history of hypertension. Countertransport was measured in healthy children and those with secondary hypertension. There was no significant difference in countertransport between these two groups. In the normal children (n = 52, median age 6.8 years), there was a positive relationship between body mass index and countertransport (rs = 0.34, p < 0.02). A positive relationship between family history of hypertension using a ranked scoring system, and countertransport, not related to age, body mass or blood pressure (n = 34, rs = 0.63, p < 0.001) was also found. There was no significant relationship between intracellular sodium concentration and countertransport. These data confirm that countertransport in normal children is related to body mass index and indicate that a genetic predisposition to primary hypertension marked by sodium-lithium countertransport is identifiable in childhood.
P N Houtman; V Shah; M J Dillon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  82     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1057-60     Citation Subset:  IM    
Department of Paediatric Nephrology, Hospital for Sick Children, London, UK.
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MeSH Terms
Blood Pressure
Body Mass Index
Child, Preschool
Erythrocytes / metabolism
Hypertension / blood,  genetics*
Lithium / blood*
Severity of Illness Index
Sodium / blood*
Reg. No./Substance:
7439-93-2/Lithium; 7440-23-5/Sodium

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