Document Detail

Sodium lithium countertransport and blood pressure. Longitudinal findings.
MedLine Citation:
PMID:  8931840     Owner:  NLM     Status:  MEDLINE    
A significant and positive association between red blood cell sodium lithium countertransport (Na-Li CT) and blood pressure has been found in numerous studies. However, the majority of the studies presented to date are cross-sectional in nature and limited information exists on the longitudinal association between Na-Li CT and blood pressure. The present study analyzes the longitudinal association between Na-Li CT and blood pressure in 124 men participants in the Olivetti Heart Study and normotensives at the baseline examination. The Na-Li CT measured at the 12 year follow-up examination was analyzed in regard to the blood pressure changes over time during the 12 year follow-up. Na-Li CT (measured at follow-up examination) was positively related to changes over time in systolic pressure (r = 0.16) and diastolic pressure (r = 0.07) and changes in body mass index (r = 0.18). When blood pressure changes over time were analyzed by tertiles of Na-Li CT, the highest tertile group exhibited on the average significantly higher increases in systolic blood pressure compared with participants of the lowest tertile of the Na-Li CT distribution. This difference remained statistically significant after adjusting for the changes in weight observed during the 12 years follow-up. These findings indicate that the Na-Li CT distribution is related to blood pressure changes over time. However, the usefulness of Na-Li CT as a predictor of incidence of hypertension remains to be established.
M Trevisan; P Strazzullo; F Cappuccio; F Jossa; R Iacone; I Russo; E Farinaro
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  9     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-18     Completed Date:  1997-02-18     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1132-5     Citation Subset:  IM    
Department of Social and Preventive Medicine, State University of New York at Buffalo, New York 14214, USA.
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MeSH Terms
Antiporters / metabolism*
Biological Transport
Blood Pressure / physiology*
Body Weight
Lithium / metabolism*
Logistic Models
Longitudinal Studies
Middle Aged
Sodium / metabolism*
Reg. No./Substance:
0/Antiporters; 0/sodium-lithium countertransporter; 7439-93-2/Lithium; 7440-23-5/Sodium

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