Document Detail


Sodium-lithium countertransport activity in healthy, dyslipidemic, and hypertensive individuals.
MedLine Citation:
PMID:  18840623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of our study was to investigate the role of dyslipidemia on red blood cell sodium-lithium countertransport activity in healthy and hypertensive individuals. A total of 128 Caucasian individuals, aged 20 to 60 years old, were divided into 4 groups: dyslipidemic/ hypertensive, dyslipidemic/normotensive, normolipidemic/hypertensive, and normolipidemic/ normotensive (controls). Sodium-lithium countertransport activity was determined based on the Canessa et al method. Sodium-lithium countertransport activity was significantly higher in all patient groups compared with controls (P < .001) and similar in the 3 patient groups. Sodium-lithium countertransport activity was significantly and positively associated with triglyceride levels (P < .001), body mass index (P < .001), total cholesterol levels (P = .001), and systolic (P = .001) and diastolic blood pressure (P = .001). In multivariate regression analysis, triglycerides made the largest contribution to sodium-lithium countertransport variation among the variables tested (R(2) = 0.273). Our results suggest that dyslipidemia affects sodium-lithium countertransport activity independently of essential hypertension and even to a greater extent than hypertension.
Authors:
Christos G Savopoulos; Apostolos I Hatzitolios; Niki A Katsiki; Maria Baltatzi; Maria Kosmidou; Nikolaos Raikos; Dimitri P Mikhailidis; Antonios G Ziakas; Georgia Kaiafa; Niki Tsesmeli
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-10-07
Journal Detail:
Title:  Angiology     Volume:  59     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:    2008 Dec-2009 Jan
Date Detail:
Created Date:  2008-12-17     Completed Date:  2009-01-09     Revised Date:  2009-02-03    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  727-35     Citation Subset:  IM    
Affiliation:
1st Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiporters / blood*
Blood Pressure
Body Mass Index
Case-Control Studies
Cholesterol / blood
Dyslipidemias / blood*,  physiopathology
Erythrocytes / metabolism*
Female
Humans
Hypertension / blood*,  physiopathology
Male
Middle Aged
Triglycerides / blood
Up-Regulation
Young Adult
Chemical
Reg. No./Substance:
0/Antiporters; 0/Triglycerides; 0/sodium-lithium countertransporter; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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