Document Detail

Sodium intake and cardiac sympatho-vagal balance in young men with high blood pressure.
MedLine Citation:
PMID:  15253104     Owner:  NLM     Status:  MEDLINE    
We have previously reported that a high sodium intake increases sleep-time blood pressure (BP) in young men. However, there are cases in which this relation does not apply. To account for them, we investigated the relation between sodium intake and cardiac sympatho-vagal balance (SVB) in young men with high BP. Sodium intake was estimated from the amount of urinary sodium excretion over 1 week. Twenty-four-hour (24-h) urinary sodium excretion (Salt24), 24-h ambulatory BP and ECG were obtained on the last day of the observation period. As an index of sodium intake, the expression In(Salt24/Cr24) (Cr24, 24-h urinary creatinine excretion) was used. From power-spectral analysis of ECG-RR intervals during sleep, we obtained the LF/HF ratio between the low-frequency component (LF) and the high frequency component (HF) and used it as an index of SVB. The subjects were male medical students divided into a normal BP group (N-group; n=103) and a high BP group (H-group; n=26, 24-h BP>125/75 mmHg). Mean In(Salt24/Cr24) and LF/HF in the H-group were significantly higher than those in the N-group (LF/HF: 1.86+/-0.44 [SD] vs. 1.37+/-0.30, p<0.001). The calculated discriminant function (D) for the H-group and N-group was D=1.6x + 5y - 11, where x is In(Salt24/Cr24) and y is LF/HF. This formula (D) resulted in high discriminant predictive accuracy (82%) between the groups. If D=0 (the value of the cut-off line determining separation of the groups), the relation y=-0.32x + 2.2 (negative relation between y and x) was obtained. These results suggest that excessive sodium intake in combination with accentuated SVB (LF/HF) increases BP in young men.
Osamu Tochikubo; Kiyoko Nishijima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  27     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-15     Completed Date:  2004-09-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  393-8     Citation Subset:  IM    
Department of Public Health, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm / physiology
Creatinine / urine
Heart / innervation,  physiology*
Hypertension / physiopathology*
Sodium, Dietary / urine*
Sympathetic Nervous System / physiology*
Vagus Nerve / physiology*
Reg. No./Substance:
0/Sodium, Dietary; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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