Document Detail

Sodium and hypertension. A review.
MedLine Citation:
PMID:  3510595     Owner:  NLM     Status:  MEDLINE    
Abnormal sodium metabolism may be critical in the causation of certain forms of hypertension, particularly salt-sensitive hypertension. Long-term restriction of sodium intake in patients at high risk for the development of hypertension may reduce the chances of established hypertension occurring later. These high-risk patients in whom subsequent hypertension may be prevented include normotensive patients with family histories of hypertension, elderly patients, black patients, and those with low-renin hypertension. Treatment of hypertension with moderate sodium restriction to 70 mEq/day will significantly reduce blood pressure in a large percentage of patients, particularly known salt-sensitive hypertensive patients. This degree of restriction is also an effective adjunctive therapy for patients receiving antihypertensive medications. There is convincing experimental, epidemiologic, and clinical evidence that moderate sodium restriction helps prevent and assists in the treatment of hypertension in those patients who are genetically predisposed to develop primary hypertension or who already have hypertension. There is no evidence that this degree of sodium restriction is harmful.
M C Houston
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Publication Detail:
Type:  Clinical Trial; Journal Article; Review    
Journal Detail:
Title:  Archives of internal medicine     Volume:  146     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-01-24     Completed Date:  1986-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-85     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Developing Countries
Diet / adverse effects*
Diet, Sodium-Restricted
Disease Susceptibility
Hypertension / epidemiology,  etiology*,  physiopathology,  prevention & control,  therapy
Patient Compliance
Sodium / adverse effects*
United States
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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