| Sodium-dependent magnesium transport across in situ perfused rat placenta. | |
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MedLine Citation:
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PMID: 1908643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Placentas of anesthetized rats were perfused in situ on the fetal side to study mechanisms of Mg2+ transport. The perfusate was a Mg(2+)-free Krebs-Ringer, and the unidirectional transfer of Mg2+ from maternal plasma to this Ringer was compared with that of 45Ca and 51Cr-EDTA, the latter being employed as a paracellular diffusional marker. Placental perfusion with amiloride (0.5 mM) or ouabain (1 mM) both rapidly (4 min) reduced maternal-fetal clearance (Kmf) for Mg2+ but had no effect on Kmf for 45Ca. In contrast, perfusion of the carbonic anhydrase inhibitor acetazolamide (1 mM) did not affect Kmf for Mg2+ or 45Ca. Placental perfusion with a Na+-free Ringer reduced Kmf for both Mg2+ and 45Ca, although the latter response was delayed. Kmf for 51Cr-EDTA was increased by amiloride and was unaffected by perfusion of ouabain, acetazolamide, or Na+-free Ringer, indicating that the effects of these treatments on Kmf of Mg2+ do not reflect nonspecific effects on placental permeability. These data suggest that maternal-fetal transfer of Mg2+ across the perfused rat placenta is Na+ dependent. |
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Authors:
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A J Shaw; M Z Mughal; M J Maresh; C P Sibley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 261 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-09-23 Completed Date: 1991-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R369-72 Citation Subset: IM |
Affiliation:
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Department of Child Health, St. Mary's Hospital, University of Manchester, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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pharmacology Amiloride / pharmacology Animals Biological Transport Calcium / pharmacokinetics Choline / pharmacology Edetic Acid / pharmacokinetics Female Magnesium / pharmacokinetics Ouabain / pharmacology Perfusion Placenta / metabolism* Pregnancy Rats Rats, Inbred Strains Sodium / physiology* |
| Chemical | |
Reg. No./Substance:
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2609-46-3/Amiloride; 59-66-5/Acetazolamide; 60-00-4/Edetic Acid; 62-49-7/Choline; 630-60-4/Ouabain; 7439-95-4/Magnesium; 7440-23-5/Sodium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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