| Sodium cromoglycate and eformoterol attenuate sensitivity and reactivity to inhaled mannitol in subjects with bronchiectasis. | |
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MedLine Citation:
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PMID: 21054671 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background and objective: Dry powder mannitol has the potential to be used to enhance clearance of mucus in subjects with bronchiectasis. A reduction in FEV(1) has been recorded in some subjects with bronchiectasis after inhaling mannitol. The aim of this study was to investigate if pre-medicating with either sodium cromoglycate (SCG) or eformoterol could inhibit this reduction in FEV(1) . Methods: A double-blind, placebo-controlled, randomized cross-over study was conducted. Lung function and airway response to mannitol was assessed on a control day and then re-assessed after pre-medication with placebo, SCG and eformoterol in nine subjects. Sensitivity to mannitol, expressed as the dose required to induce a 15% fall in FEV(1) (PD(15) ), and reactivity to mannitol, expressed as the % fall in FEV(1) per mg of mannitol (response-dose ratio, RDR), are reported. Results: Subjects had an FEV(1) of 68 ± 14% predicted, FVC of 97 ± 15% predicted and FEV(1) /FVC of 71 ± 8%. They were mildly hypoxemic and the SpO(2) was 95 ± 2%.They had a PD(15) to mannitol of 235 mg (95% CI: 150-368 mg) and a RDR of 0.057% fall in FEV(1) per mg (95% CI: 0.038-0.085). After pre-medication with SCG, PD(15) increased (773 mg, P < 0.05) and RDR was reduced (0.013, P < 0.05). Pre-medication with eformoterol also resulted in an increased PD(15) (1141 mg, P < 0.01) and a reduced RDR (0.009, P < 0.01). A small but significant decrease in SpO(2) from baseline was noted after mannitol in the presence of SCG (P < 0.05). Conclusions: Pre-medication with either SCG or eformoterol protects patients with bronchiectasis from developing a significant reduction in FEV(1) after inhaling mannitol. |
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Authors:
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Peter J Briffa; Sandra D Anderson; Deborah L Burton; Iven H Young |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: 16 ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-04-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: Australia |
Other Details:
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Languages: eng Pagination: 161-6 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Respirology © 2010 Asian Pacific Society of Respirology. |
Affiliation:
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Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown School of Biomedical Sciences, Charles Sturt University, Orange, New South Wales, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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