Document Detail

Sodium butyrate stimulates hCG and hCG-alpha production in a human choriocarcinoma cell line (BeWo).
MedLine Citation:
PMID:  7196916     Owner:  NLM     Status:  MEDLINE    
To assess regulatory mechanism(s) of hormone production between ectopic and eutopic tumor cells, the effect of sodium butyrate on cell growth and hormone production was studied in BeWo, a trophoblastic cell line and in HeLa S3, a nontrophoblastic cell line. The addition of 2 mM sodium butyrate to HeLa S3 produced a marked increase in hCG-alpha both in the medium and in the cell extract, in contrast to its inhibitory effects on cell growth. Sodium butyrate had a similar effect on cell growth and hormone secretion in BeWo cells, as seen with an increase in release of hCG and hCG-alpha were also increased after exposure to sodium butyrate in BeWo. Thus, the regulation of hormone production in trophoblastic and nontrophoblastic tumor cells probably does not differ.
F Kinoshita; Y Nakai; O Nikaido; H Imura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  100     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1981  
Date Detail:
Created Date:  1981-11-24     Completed Date:  1981-11-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  321-4     Citation Subset:  IM    
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MeSH Terms
Butyrates / pharmacology*
Cell Division / drug effects
Cell Line
Choriocarcinoma / metabolism*
Chorionic Gonadotropin / biosynthesis*
Hela Cells / metabolism
Uterine Neoplasms / metabolism*
Reg. No./Substance:
0/Butyrates; 0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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