Document Detail


Sodium butyrate stimulates cellular recovery from UV damage in xeroderma pigmentosum cells belonging to complementation group F.
MedLine Citation:
PMID:  3117749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Possible stimulation of the DNA repair capacity by sodium butyrate in normal and xeroderma pigmentosum (XP) cells was investigated. XP cells belonging to the complementation group F showed considerable stimulation of DNA repair by sodium butyrate in terms of both the amount of unscheduled DNA synthesis (UDS) and the colony-forming ability after UV irradiation. UDS in XP cells belonging to the complementation group A was not enhanced, while normal cells showed slight enhancement, but less than that of XP F cells. In XP A, XP C, and normal cells, sodium butyrate treatment enhanced the killing effect of UV irradiation. The residual repair capacity in XP F cells appeared to be stimulated by sodium butyrate.
Authors:
C Nishigori; H Takebe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of cancer research : Gann     Volume:  78     ISSN:  0910-5050     ISO Abbreviation:  Jpn. J. Cancer Res.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-12-11     Completed Date:  1987-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8509412     Medline TA:  Jpn J Cancer Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  932-6     Citation Subset:  IM    
Affiliation:
Department of Experimental Radiology and Molecular Oncology, Faculty of Medicine, Kyoto University.
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MeSH Terms
Descriptor/Qualifier:
Butyrates / pharmacology*
Butyric Acid
Butyric Acids / pharmacology*
Cell Survival / drug effects,  radiation effects
Cells, Cultured
DNA Replication / drug effects,  radiation effects
Female
Fibroblasts / cytology,  drug effects,  radiation effects
Genetic Complementation Test
Humans
Male
Ultraviolet Rays*
Xeroderma Pigmentosum / genetics,  pathology*
Chemical
Reg. No./Substance:
0/Butyrates; 0/Butyric Acids; 107-92-6/Butyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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