Document Detail


Sodium, blood pressure, and ethnicity: what have we learned?
MedLine Citation:
PMID:  19593737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An enormous amount of research has yielded significant knowledge about ethnic differences in sodium homeostasis and blood pressure regulation. Consistent findings such as greater sodium-sensitivity, lower potassium excretion and high higher serum sodium levels in African Americans need further exploration to define more precise physiological mechanisms. The genetic alleles associated with sodium homeostasis in relation to blood pressure have accounted for only a small proportion of the variance in blood pressure. Several allelic variants differ in frequency among ethnic groups and heat-adapted genetic variants have a high prevalence in low latitudes and hot, wet climates which lends support to the "sodium retention" hypothesis. The blood pressure disparities between African Americans and whites may, in part, be due to different allelic frequencies of genes associated with sodium homeostasis. However, with advances in genomics, environmental factors tend to be neglected in research. Better measures of environmental stress have recently been developed by anthropologists and should be included in research designs by investigators in other disciplines. Public health efforts should encourage food producers to reduce sodium content of its products, and physicians should encourage patients to reduce consumption of high sodium packaged and fast foods.
Authors:
Lillian Gleiberman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  21     ISSN:  1520-6300     ISO Abbreviation:  Am. J. Hum. Biol.     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  679-86     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48106, USA. lillig@umich.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans*
Anthropology, Physical
Blood Pressure / genetics*
Cross-Cultural Comparison
European Continental Ancestry Group*
Evolution
Female
Humans
Hypertension / ethnology,  genetics
Male
Phenotype
Polymorphism, Single Nucleotide
Sodium / metabolism*
Stress, Psychological / ethnology,  genetics
Tropical Climate
Water-Electrolyte Balance / genetics*
Chemical
Reg. No./Substance:
7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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