| Sodium bicarbonate in cardiac arrest: a reappraisal. | |
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MedLine Citation:
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PMID: 8924147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The routine use of sodium bicarbonate in patients with cardiac arrest has been discouraged, with the benefit of outcome evaluation. Current recommendations include an elaborate stratification of circumstances in which bicarbonate is to be used. The physiological and clinical aspects of bicarbonate administration during cardiopulmonary resuscitation in animal and human studies were reviewed. The onset of significant acidemia or alkalemia is associated with adverse system specific effects. The administration of bicarbonate may mitigate the adverse physiological effects of acidemia, improve response to exogenously administered vasopressor agents, or simply increase venous return due to an osmolar effect, resulting in increased coronary perfusion pressure. Likewise, bicarbonate may have adverse effects in each of these areas. The preponderance of evidence suggests that bicarbonate is not detrimental and may be helpful to outcome from cardiac arrest. An objective reappraisal of the empirical use of bicarbonate or other buffer agents in the appropriate "therapeutic window" for cardiac patients may be warranted. |
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Authors:
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R B Vukmir; N Bircher; P Safar |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of emergency medicine Volume: 14 ISSN: 0735-6757 ISO Abbreviation: Am J Emerg Med Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-11-13 Completed Date: 1996-11-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309942 Medline TA: Am J Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 192-206 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh Medical Center, PA 15213-2582, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium Acidosis / drug therapy Animals Central Nervous System / drug effects Disease Models, Animal Heart / drug effects Heart Arrest / drug therapy*, metabolism, physiopathology* Hemodynamics / drug effects Humans Lung / drug effects Myocardium / metabolism Sodium Bicarbonate / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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144-55-8/Sodium Bicarbonate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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