Document Detail

Sodium and bicarbonate fluxes in regenerating rabbit corneal endothelium.
MedLine Citation:
PMID:  3595179     Owner:  NLM     Status:  MEDLINE    
Rabbit corneal endothelia were subjected to a cryoinjury (-70 degrees C for 15 sec) and sodium and bicarbonate fluxes were determined at various times after induction of the endothelial destruction. A complete monolayer of cells was present by 4 days that consisted of large cells that underwent division over the next 16 days. Unidirectional sodium fluxes were unaltered by the transformation from large to normal sized hexagonal cells. Unidirectional bicarbonate fluxes showed an increase in Jendostr coupled with a decrease in the net Jstrendo flux. As the cells became smaller these bicarbonate fluxes returned to normal values. The data indicate that the cell margin/cell size ratio is not related to the flux rates, thus the paracellular pathway increase with healing is not related to the passage of either sodium or bicarbonate. Secondly, the data indicate separate effects on both sodium and bicarbonate, suggesting that transendothelial movement of the ions can be separated and that they are not necessarily linked in passage across the endothelium.
K Green; A M Reynolds; L Cheeks; B Forbes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Current eye research     Volume:  6     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-07     Completed Date:  1987-08-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  675-81     Citation Subset:  IM    
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MeSH Terms
Bicarbonates / metabolism*
Cornea / injuries*,  metabolism,  pathology,  physiopathology
Endothelium / metabolism,  pathology,  physiopathology
Sodium / metabolism*
Grant Support
Reg. No./Substance:
0/Bicarbonates; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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