Document Detail

Sodium benzoate-induced repeated episodes of acute urticaria/angio-oedema: randomized controlled trial.
MedLine Citation:
PMID:  15491435     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sodium benzoate (E 211) is widely used to delay yeast spoilage of acidic foods and beverages. Numerous cases of adverse reactions to benzoate have been recorded, but most of the studies that have been conducted lacked proper placebo controls or blinding. OBJECTIVE: The aim of this study is to determine the incidence of intolerance to sodium benzoate among subjects who experienced repeated episodes of acute urticaria/angio-oedema following the ingestion of a meal or a product containing this substance. METHODS: This was a retrospective study based on the analysis of data from patients reported to have experienced episodes of urticaria, with or without angio-oedema, after ingesting meals or products containing sodium benzoate. At the first visit to the outpatients clinic, a careful history was taken. Patients were then given the following diagnostic tests: tests for IgE for common inhalant allergens and food allergens, and a double-blind, placebo-controlled challenge with sodium benzoate. RESULTS: A total of 47 subjects were enrolled in the study; five (11%) showed at least one relevant positive reaction to an IgE test for food allergy. Only one subject (2%) had a reaction after the ingestion of 75 mg of sodium benzoate without an adverse reaction to placebo. CONCLUSION: This study shows that the percentage of repeated episodes of acute urticaria/angio-oedema reactions induced by sodium benzoate is very low (2%). In view of our results, we suggest that when faced with patients who have suffered adverse reactions that could be attributed to sodium benzoate, physicians should also carefully evaluate other possible causes.
E Nettis; M C Colanardi; A Ferrannini; A Tursi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of dermatology     Volume:  151     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-19     Completed Date:  2005-02-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  898-902     Citation Subset:  IM    
Department of Medical Clinics, Immunology and Infectious Diseases, Section of Allergy and Clinical Immunology, University of Bari, Cattedra di Allergologia e Immunologia Clinica, Padiglione Chini-Policlinico, Bari, Italy.
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MeSH Terms
Acute Disease
Angioedema / chemically induced*
Double-Blind Method
Drug Eruptions / etiology*
Food Additives / adverse effects*
Food Hypersensitivity / diagnosis
Immunoglobulin E / biosynthesis
Middle Aged
Retrospective Studies
Skin Tests / methods
Sodium Benzoate / adverse effects*,  diagnostic use
Urticaria / chemically induced*
Reg. No./Substance:
0/Food Additives; 37341-29-0/Immunoglobulin E; 532-32-1/Sodium Benzoate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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