| Sodium alginate as viscosity modifier may induce aggregation of red blood cells. | |
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MedLine Citation:
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PMID: 20831352 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Viscosity of blood substitutes is among the important determinants to restore microcirculation. Sodium alginate (SA) is always mentioned as "viscosity modifier" in creating blood substitutes. In the present study, the whole blood was diluted using SA solutions to final hematocrits of 10%, 20%, and 35%, respectively. The whole blood viscosity (WBV) at different shear rates, plasma viscosity (PV), and rheological behavior of red blood cells (RBCs) was studied in vitro. The results show that SA may induce RBCs aggregation in a dose-dependent manner. Furthermore, the effect of SA on RBCs aggregation maybe involve the regulation of microcirculation. |
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Authors:
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Lian Zhao; Guoxing You; Fulong Liao; Xuemei Kan; Bo Wang; Quanmei Sun; Huibin Xu; Dong Han; Hong Zhou |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 38 ISSN: 1532-4184 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: England |
Other Details:
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Languages: eng Pagination: 267-76 Citation Subset: IM |
Affiliation:
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Department of Immunohematology, Beijing Institute of Transfusion Medicine, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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