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Sodium Supplementation In Neonates With Pierre Robin Sequence Significantly Improves Weight Gain If urinary Sodium Is Low.
MedLine Citation:
PMID:  21265661     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: Does sodium supplementation increase weight gain in babies with Grade 3 Pierre Robin Sequence if their urinary sodium is low? Design: Retrospective review of all medical, dietician and nursing notes of babies admitted between 2000-2007 inclusive. Setting: Tertiary center for cleft care Patients: 33 babies requiring nasogastric(ng) and nasopharangeal intubation(npa) for PRS were identified. Those in whom weights could not be measured accurately (n=4), were excluded from further study. Interventions: Urinary sodium was low and weight gain poor in 21 of the remaining 29 babies (72%) and oral sodium supplementation was given to establish and maintain a normal urinary sodium (10 - 20mmol/l). Main Outcome Measure: Mean daily weight gain. Results: The mean daily weight gain of the 18 babies with low urinary sodium admitted in the first few days of life improved from 20 grams to 34 grams (p< 0.001) following oral sodium supplementation. This gave a mean difference of 14g (lower quartile 6g, upper quartile 25g, 95% confidence interval 20, 90% confidence interval 10). The mean daily weight gain of the eight patients who did not require sodium supplementation was 33.6grams. Conclusions: Urinary sodium tests are simple and noninvasive and allow monitoring of urinary sodium. If low, adequate supplementation improved weight gain (p<0.001), reversing failure to thrive in babies with severe Pierre Robin Sequence. These findings are previously unreported. Key Words: Pierre Robin Sequence, sodium, failure to thrive.
Authors:
Joanna M Skillman; Rona Slator
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-25
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  -     ISSN:  1545-1569     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Birmingham Children's Hospital.
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