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Sodium Sulfite Enhances Rhinovirus-Induced Chemokine Production in Airway Epithelial Cells.
MedLine Citation:
PMID:  22898886     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated the effects of sodium sulfite (Na(2)SO(3)) on rhinovirus (RV)-induced chemokine production in A549 airway epithelial cells. Our results demonstrated that the treatment of A549 cells with 2,500 μM Na(2)SO(3) enhanced the mRNA expression of RV-induced interleukin (IL)-8 1.8 fold (p = 0.025); and regulated on activation, normal T cell expressed and secreted (RANTES), 2.9 fold (p = 0.025). Moreover, the secretion of IL-8, RANTES, and interferon-γ-inducible protein (IP)-10 was increased in a statistically significant manner without affecting cell viability and RV replication. Our results suggest that Na(2)SO(3) may potentiate RV infection by enhancing chemokine production.
Authors:
Yoon Hong Chun; Hyun Sook Kim; Huisu Lee; Sulmui Won; Jong-Seo Yoon; Hyun Hee Kim; Jin Tack Kim; Joon Sung Lee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-18
Journal Detail:
Title:  Bulletin of environmental contamination and toxicology     Volume:  -     ISSN:  1432-0800     ISO Abbreviation:  Bull Environ Contam Toxicol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0046021     Medline TA:  Bull Environ Contam Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, School of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Republic of Korea.
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