Document Detail

Sodium sensitivity of blood pressure in Chinese populations.
MedLine Citation:
PMID:  20424958     Owner:  NLM     Status:  MEDLINE    
Clinical trials have demonstrated that a reduced intake of dietary sodium lowers blood pressure. However, blood pressure reduction in response to a decrease in dietary sodium intake varies considerably among different individuals-a phenomenon described as sodium sensitivity. The Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study was a large family-based dietary-feeding study conducted in rural north China. This study indicated that approximately 39% of Chinese adults were sodium-sensitive. Sodium sensitivity was more common in women and in persons who were older and had higher usual blood pressure. Sodium sensitivity was also more common in individuals with higher responses to a cold pressor test and in individuals with the metabolic syndrome. Genetic factors may play an important role in determining sodium sensitivity in the Chinese population. A better understanding of the genetic and environmental determinants of sodium sensitivity has important public health and clinical implications.
Jing Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Current hypertension reports     Volume:  12     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2011-06-13     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  IM    
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MeSH Terms
Age Factors
Blood Pressure*
China / epidemiology
Confidence Intervals
Hypertension / chemically induced,  diet therapy*,  epidemiology
Life Style
Metabolic Syndrome X
Middle Aged
Multivariate Analysis
Nutrition Surveys
Nutritional Status
Odds Ratio
Rural Population
Sex Factors
Sodium Chloride, Dietary / adverse effects,  metabolism*
Grant Support
P20-RR017659/RR/NCRR NIH HHS; R01 HL087263/HL/NHLBI NIH HHS; R01 HL087263-01/HL/NHLBI NIH HHS; R01 HL087263-02/HL/NHLBI NIH HHS; R01 HL087263-02W1/HL/NHLBI NIH HHS; R01 HL087263-03/HL/NHLBI NIH HHS; R01 HL087263-04/HL/NHLBI NIH HHS; R01 HL090682/HL/NHLBI NIH HHS; R01 HL090682-01A1/HL/NHLBI NIH HHS; R01 HL090682-01A1W1/HL/NHLBI NIH HHS; R01 HL090682-02/HL/NHLBI NIH HHS; R01 HL090682-03/HL/NHLBI NIH HHS; R01HL087263/HL/NHLBI NIH HHS; R01HL090682/HL/NHLBI NIH HHS; U01 HL072507/HL/NHLBI NIH HHS; U01 HL072507-01/HL/NHLBI NIH HHS; U01 HL072507-02/HL/NHLBI NIH HHS; U01 HL072507-03/HL/NHLBI NIH HHS; U01 HL072507-03S1/HL/NHLBI NIH HHS; U01 HL072507-04/HL/NHLBI NIH HHS; U01 HL072507-04S1/HL/NHLBI NIH HHS; U01 HL072507-05/HL/NHLBI NIH HHS; U01 HL072507-06/HL/NHLBI NIH HHS; U01HL072507/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Sodium Chloride, Dietary

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