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Sodium Nitrate Supplementation Does Not Enhance Performance of Endurance Athletes.
MedLine Citation:
PMID:  22811030     Owner:  NLM     Status:  Publisher    
PURPOSE: Supplementation with inorganic nitrate has been suggested to be an ergogenic aid for athletes as nitric oxide donor. The purpose of this study was to determine whether ingestion of inorganic sodium nitrate benefits well-trained athletes performing a 40-minute exercise test in laboratory conditions. Additionally, we investigated the effect of this supplement on plasma levels of endothelin-1 and in nitrated-proteins. METHODS: Thirteen trained athletes participated in this randomised, double-blind, crossover study. They performed a 40-minute cycle ergometer distance-trial test after two 3-day periods of dietary supplementation with sodium nitrate (10 mg·kg of body mass) or placebo. RESULTS: Concentration of plasma nitrate (256 ± 35 μM) and nitrite (334 ± 86 nM) increased significantly (P < 0.05) after nitrate supplementation compared with placebo (nitrate: 44 ± 11 μM; nitrite: 187 ± 43 nM). In terms of exercise performance, there were no differences in either the mean distance (nitrate: 26.4 ± 1.1 km; placebo: 26.3 ± 1.2 km; P = 0.61) or mean power output (nitrate: 258 ± 28 W; placebo: 257 ± 28 W; P = 0.89) between treatments. Plasma endothelin-1 increased significantly (P < 0.05) just after exercise in nitrate (4.0 ± 0.8 pg·ml) and placebo (2.4 ± 0.4 pg·ml) conditions. This increase was significantly greater (P < 0.05) in the nitrate group. Levels of nitrated-proteins did not differ between treatments (nitrate: pre-exercise: 91 ± 23%; post-exercise: 81 ± 23 %; placebo: pre-exercise: 95 ± 20%; post-exercise: 99 ± 19 %). CONCLUSION: Sodium nitrate supplementation did not improve a 40-minute distance-trial performance in endurance athletes. In addition, concentration of plasma endothelin-1 increased significantly after exercise following supplementation with sodium nitrate.
Raúl Bescós; Ventura Ferrer-Roca; Pedro A Galilea; Andreu Roig; Franchek Drobnic; Antoni Sureda; Miquel Martorell; Alfredo Cordova; Josep A Tur; Antoni Pons
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-17
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 National Institute of Physical Education INEFC-Barcelona. Research Group on Sport Sciences. University of Barcelona, Barcelona, Spain. 2 High Performance Center of Barcelona. Performance and Health Research Group for High Level Sports, Sant Cugat, Spain. 3 Laboratory of Physical Activity Science. Research Group on Community Nutrition and Oxidative Stress. University of the Balearic Islands, Palma de Mallorca, Spain. 4 Department of Physiology and Biochemistry, School of Physiotherapy. University of Valladolid, Valladolid, Spain.
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