Document Detail

Sodium Bicarbonate Solution versus Chlorhexidine Mouthwash in Oral Care of Acute Leukemia Patients Undergoing Induction Chemotherapy: A Randomized Controlled Trial.
MedLine Citation:
PMID:  25030829     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: The objective of this study was to compare the effectiveness of sodium bicarbonate (SB) solution with chlorhexidine (CHX) mouthwash in oral care of acute leukemia patients under induction chemotherapy.
METHODS: Forty-eight patients were randomly selected and assigned to an SB solution group or CHX-based product group according to acute myelogenous leukemia or acute lymphoblastic leukemia. Patients were asked to rinse their mouth four times a day from the day before chemotherapy started until discharge. The World Health Organization mucositis grade, patient-reported Oral Mucositis Daily Questionnaire, and clinical signs associated with infection were assessed on a daily basis. The oral microbial count was assessed on a weekly basis from the 1st day of chemotherapy started to the 28th day or to the day of discharge from the hospital.
RESULTS: Of all the patients in the SB group, 25.0% developed ulcerative oral mucositis, whereas 62.5% in the CHX group did. The onset of oral mucositis was later in the SB group than the CHX group. The oral bacterial colonization in the SB group was significantly higher than that in the CHX group, but clinical signs associated with infection did not differ in both groups.
CONCLUSION: As a result of this study, it was found that oral care by SB solution for acute leukemia patients undergoing chemotherapy was an effective intervention to improve oral health.
So-Eun Choi; Hee-Seung Kim
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Publication Detail:
Type:  Journal Article     Date:  2012-05-24
Journal Detail:
Title:  Asian nursing research     Volume:  6     ISSN:  1976-1317     ISO Abbreviation:  Asian Nurs Res (Korean Soc Nurs Sci)     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2014-07-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101321326     Medline TA:  Asian Nurs Res (Korean Soc Nurs Sci)     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  60-6     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
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